Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatordos Santos, Aline Martins-
Autor(es): dc.creatorCarvalho, Suzana Gonçalves-
Autor(es): dc.creatorFerreira, Leonardo Miziara Barboza-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorGremião, Maria Palmira Daflon-
Data de aceite: dc.date.accessioned2025-08-21T21:57:29Z-
Data de disponibilização: dc.date.available2025-08-21T21:57:29Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfa.2022.128417-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234093-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234093-
Descrição: dc.descriptionJudicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties of 5-fluorouracil (5-FU) on the formation and properties of CS-TPP nanoparticles. The effect of synthesis variables of CS-TPP nanoparticles (CS to TPP ratio and order of addition) under pH 4.5 and 5.5 was evaluated, where CS and TPP were charged, and 5-FU had two different charges (positive and negative), maximizing the interactions between them for the formation of nanoparticles. The order of addition and drug location resulted in changes in the interaction forces, influencing the particle size and size distribution. 5-FU addition into CS resulted in stronger interactions, favoring the formation of smaller particles. The pH of reactional medium and CS to TPP ratio affected the properties of particles, in terms of size and potential zeta, which led to greater 5-FU entrapment. These results demonstrated that the particle properties still depends of the synthesis factors, but the physicochemical properties of drug also influence the reactions/interactions involved in the formation of CS-TPP nanoparticles.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionNanomedicine and Nanotoxicology Group (GNANO) University of São Paulo (USP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionFAPESP: 2016/01464-9-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces A: Physicochemical and Engineering Aspects-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChitosan-based nanoparticles-
Palavras-chave: dc.subjectElectrostatic interactions-
Palavras-chave: dc.subjectIonic crosslinking-
Palavras-chave: dc.subjectSodium tripolyphosphate-
Título: dc.titleUnderstanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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