Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNIGRAN-
Autor(es): dc.contributorUniversidade Estadual de Mato Grosso do Sul (UEMS)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUFGD-
Autor(es): dc.creatorStein, Julia-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorCasali Reis, Ana Carolina-
Autor(es): dc.creatorSantos Radai, Joyce Alencar-
Autor(es): dc.creatorda Silva Moreira, Suyane-
Autor(es): dc.creatorFraga, Thiago Leite-
Autor(es): dc.creatorda Silva Mota, Jonas-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T15:23:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:23:37Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2022.105118-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/234025-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/234025-
Descrição: dc.descriptionPiper amalago L. (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, and antiparasitic properties. However, few studies have focused on its adverse effects, compromising its safe use. This study evaluated the toxicological safety of ethanolic extract from Piper amalago leaves (EEPA), through subacute toxicity and genotoxicity assays in rodents. In subacute toxicity, 100, 200 or 300 mg/kg of EEPA were tested in female Wistar rats, by gavage, for 28 days. For genotoxicity test, female Swiss mice were orally treated with 17.5, 175 or 1750 mg/kg of EEPA and the comet, micronucleus, and splenic phagocytic assays were evaluated. In subacute toxicity, the extract induced an increase in the food and water intakes, as well as in the liver absolute weight, and in the heart and kidney relative weights. EEPA also provoked alterations in histopathological analysis of liver and in hemato-biochemical parameters, evidenced by a decrease in hematocrit levels and albumin levels, and an increase in the number of platelets and in alkaline phosphatase and cholesterol levels. However, EEPA did not presented genotoxic nor mutagenic properties. EEPA showed hemato-biochemical toxicity profile in rats and should be used with caution, especially when for prolonged period.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu UNESP – Univ. Estadual Paulista - Botucatu, São Paulo State-
Descrição: dc.descriptionSchool of Health Sciences University Center of Grande Dourados UNIGRAN-
Descrição: dc.descriptionMato Grosso do Sul State University UEMS-
Descrição: dc.descriptionFederal University of Mato Grosso do Sul UFMS-
Descrição: dc.descriptionSchool of Health Sciences Federal University of Grande Dourados UFGD-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu UNESP – Univ. Estadual Paulista - Botucatu, São Paulo State-
Descrição: dc.descriptionCNPq: #304266/2017–5-
Descrição: dc.descriptionCNPq: #311166/2016–4-
Descrição: dc.descriptionCNPq: #427859/2018–2-
Idioma: dc.languageen-
Relação: dc.relationRegulatory Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectHemato-biochemical alterations-
Palavras-chave: dc.subjectHepatotoxicity-
Palavras-chave: dc.subjectMice-
Palavras-chave: dc.subjectPiper amalago-
Palavras-chave: dc.subjectPiperaceae-
Palavras-chave: dc.subjectRats-
Palavras-chave: dc.subjectSafety-
Palavras-chave: dc.subjectSubacute toxicity-
Título: dc.titleEvaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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