Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorRuiz, Thalles Fernando Rocha-
Autor(es): dc.creatorLeonel, Ellen Cristina Rivas-
Autor(es): dc.creatorColleta, Simone Jacovaci-
Autor(es): dc.creatorBedolo, Carolina Marques-
Autor(es): dc.creatorPegorin de Campos, Silvana Gisele-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Data de aceite: dc.date.accessioned2025-08-21T21:02:47Z-
Data de disponibilização: dc.date.available2025-08-21T21:02:47Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.etap.2021.103785-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233894-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233894-
Descrição: dc.descriptionIn the mammary gland (MG), the developmental window for gestational/lactational differentiation and growth is highly vulnerable to hormonal disruption. Here we describe that the MG involution process in female gerbil mothers is delayed by bisphenol A (BPA) exposure during gestation and lactation. The process is directly influenced by changes in expression of extracellular matrix proteases MMP-2, MMP-9, and FAP, and the incidence of collagen and elastin is reduced after 7 and 14 days of weaning. A pro-inflammatory environment in the late involution process was confirmed by higher expression of TNF-α, COX-2 and phospho-STAT3 n the MG stroma, allied to increases in the incidence of macrophages and mast cells. These aspects impacted the proliferative pattern of epithelial cells, which decreased on the 14th post-weaning day. These data confirm that the milk production window of susceptibility is vulnerable to the impact of BPA, which promotes a suggestive pro-tumoral microenvironment during mammary involution.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265, Jardim Nazareth-
Descrição: dc.descriptionDepartment of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás (UFG), Avenida Esperança, s/n, Câmpus Samambaia-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265, Jardim Nazareth-
Descrição: dc.descriptionFAPESP: 2018/23383–6-
Descrição: dc.descriptionFAPESP: 2020/01240–9-
Descrição: dc.descriptionCNPq: 302938/2020/6-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBisphenol A-
Palavras-chave: dc.subjectEndocrine disruptor-
Palavras-chave: dc.subjectEstradiol-
Palavras-chave: dc.subjectExtracellular matrix-
Palavras-chave: dc.subjectInflammation-
Título: dc.titleGestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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