Palonosetron versus ondansetron for prophylaxis of postoperative nausea and vomiting in laparoscopic cholecystectomy: a non-inferiority randomized controlled trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDavolos, Francisco José Chiaradia-
Autor(es): dc.creatorModolo, Norma S.-
Autor(es): dc.creatorBraz, Leandro G.-
Autor(es): dc.creatorNascimento Junior, Paulo do-
Data de aceite: dc.date.accessioned2025-08-21T20:24:17Z-
Data de disponibilização: dc.date.available2025-08-21T20:24:17Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bjane.2021.06.020-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233889-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233889-
Descrição: dc.descriptionBackground: We tested the hypothesis that, within the margin of 15% of risk difference, palonosetron is not inferior to ondansetron in reducing the incidence of postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy. Methods: We conducted a double-blind, non-inferiority, randomized, controlled trial of 212 patients aged 18 to 65 years undergoing laparoscopic cholecystectomy under general anesthesia in two secondary care hospitals. Patients were randomly assigned to receive either palonosetron (0.075 mg) or ondansetron (8 mg) intravenously at induction of anesthesia. Ondansetron (8 mg) was also administered 8 and 16 hours postoperatively. All anesthetic and surgical procedures were standardized. Patients were evaluated for 24 hours postoperatively for the occurrence of PONV. Results: A high incidence of PONV was observed at 2–6 hours postoperatively, with a rate of 36.8% (95% confidence interval [CI] 28.2–46.3) in the palonosetron group, as compared to 43.4% (95% CI 34.4–52.9) in the ondansetron group. The risk difference (95% CI) between palonosetron and ondansetron for PONV was 0 (-10.9 to 10.9) at 0–2 hours, -6.6 (-19.4 to 6.5) at 2–6 hours, -0.9 (-11.0 to 9.2) at 6–12 hours, and -2.8 (-9.6 to 3.6) at 12–24 hours. There was no statistically significant difference between the palonosetron and ondansetron groups in the use of rescue medication (dimenhydrinate). There were no adverse events associated with the medications under study. Conclusion: Palonosetron is not inferior to ondansetron in patients at risk of PONV undergoing laparoscopic cholecystectomy, providing a good option for PONV prophylaxis, as it can be administered in a single dose.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Departamento Especialidades Cirúrgicas e Anestesiologia-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Departamento Especialidades Cirúrgicas e Anestesiologia-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Anesthesiology (English Edition)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiemetics-
Palavras-chave: dc.subjectPostoperative nausea and vomiting-
Palavras-chave: dc.subjectPre-exposure prophylaxis-
Palavras-chave: dc.subjectRisk factors-
Palavras-chave: dc.subjectTherapeutics-
Título: dc.titlePalonosetron versus ondansetron for prophylaxis of postoperative nausea and vomiting in laparoscopic cholecystectomy: a non-inferiority randomized controlled trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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