In vitro inhibition of acetylcholinesterase and monoamine oxidase by Syzygium cumini leaves extract and preliminary assessment in animal models

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorBorba, Laryssa Alves-
Autor(es): dc.creatorWiltenburg, Victor Distefano-
Autor(es): dc.creatorNegri, Giuseppina-
Autor(es): dc.creatorIbe, Mariana Bittencourt-
Autor(es): dc.creatorSantos, Lucinéia dos-
Autor(es): dc.creatorMendes, Fúlvio Rieli-
Data de aceite: dc.date.accessioned2025-08-21T21:32:02Z-
Data de disponibilização: dc.date.available2025-08-21T21:32:02Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.sajb.2021.11.041-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233878-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233878-
Descrição: dc.descriptionSyzygium cumini (Myrtaceae) is a tropical tree used in traditional medicines to treat several diseases. All parts of S. cumini are used for medicinal purposes and present antioxidant potential. In this study, we evaluated the phytochemical composition of the ethanolic extract of S. cumini leaves (EESC) and its biological activity in vitro and in vivo regarding some effects on the central nervous system. Behavioral tests of anxiety, depression, and memory were performed with mice and the cerebral cortex used to evaluate lipoperoxidation and the acetylcholinesterase activity ex vivo. The EESC showed the presence of flavonoids, tannins, and gallic acid esters-4-O-glucurosides, detected for the first time in the species. The EESC presented antioxidant capacity in vitro with EC50 of 82.8 μg/mL in the DPPH assay and IC50 of 1.27 μg/mL in the lipoperoxidation test. The EESC inhibited the in vitro acetylcholinesterase and monoamine oxidase activities presenting IC50 of 44.54 and 432.7 μg/mL, respectively. However, the EESC did not show significant effects on the behavioral tests and ex vivo assays. Our results confirm the potential of EESC as a source of bioactive compounds acting on important target enzymes for central nervous system disorders, but the in vivo effects must be better evaluated.-
Descrição: dc.descriptionDepartment of Biotechnology School of Sciences Humanities and Languages São Paulo State University (UNESP), Avenida Dom Antônio, 2100-
Descrição: dc.descriptionCentro de Ciências Naturais e Humanas Universidade Federal do ABC, Rua Arcturus, 03-
Descrição: dc.descriptionDepartamento de Medicina Preventiva Universidade Federal de São Paulo, Rua Botucatu, 740, 4º andar-
Descrição: dc.descriptionDepartment of Biotechnology School of Sciences Humanities and Languages São Paulo State University (UNESP), Avenida Dom Antônio, 2100-
Formato: dc.format553-563-
Idioma: dc.languageen-
Relação: dc.relationSouth African Journal of Botany-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcetylcholinesterase inhibition-
Palavras-chave: dc.subjectFlavonoids glycosides-
Palavras-chave: dc.subjectHydrolysable tannins-
Palavras-chave: dc.subjectMonoamine oxidase inhibition-
Palavras-chave: dc.subjectSyzygium cumini-
Título: dc.titleIn vitro inhibition of acetylcholinesterase and monoamine oxidase by Syzygium cumini leaves extract and preliminary assessment in animal models-
Tipo de arquivo: dc.typelivro digital-
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