Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFranca, Maria G. A.-
Autor(es): dc.creatorPessoa, Cláudia O.-
Autor(es): dc.creatorTrevisan, Maria T. S.-
Autor(es): dc.creatorPaiva, Cristiane F.-
Autor(es): dc.creatorLima, Daniele R.-
Autor(es): dc.creatorSousa, Anderson F.-
Autor(es): dc.creatorOliveira, Fátima C. E.-
Autor(es): dc.creatorCavalheiro, Alberto J.-
Autor(es): dc.creatorSilva, Maria G. V.-
Data de aceite: dc.date.accessioned2025-08-21T19:53:59Z-
Data de disponibilização: dc.date.available2025-08-21T19:53:59Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2021.2005052-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233829-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233829-
Descrição: dc.descriptionIn this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities performed by the DPPH and ABTS methods showed that the extracts possess good antioxidant activity, with emphasis on the S. macranthera extract, which obtained results very similar to the rutin pattern. In the evaluation of the cytotoxic activity, the species S. spectabilis var. excelsa presented expressive cytotoxicity against the cellular lines PC3 and HL60 with IC50 values 21.08 and 31.37 μg mL−1, respectively. The results of anticholinesterase activity showed that both the plants induced enzyme inhibition, reaching 14 mm of inhibition in the case of S. spectabilis var. excelsa. The good results obtained in this work may be related to the presence of compounds such as apigenin-7-apioglucoside, quercetin 3,4'-diglucoside, cassine and spectaline identified in the extracts in our previous work.-
Descrição: dc.descriptionDepartment of Organic and Inorganic Chemistry/Department of Analytical Chemistry and Physical-Chemistry Federal University of Ceará-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Federal University of Ceará-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacetylcholinesterase-
Palavras-chave: dc.subjectantioxidant-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectSenna-
Título: dc.titleChemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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