Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: A cross-sectional study

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Industrial de Santander-
Autor(es): dc.contributorSacred Heart University Center-
Autor(es): dc.creatorHeubel, Alessandro Domingues-
Autor(es): dc.creatorViana, Ariane Aparecida-
Autor(es): dc.creatorLinares, Stephanie Nogueira-
Autor(es): dc.creatordo Amaral, Vanessa Teixeira-
Autor(es): dc.creatorSchafauser, Nathany Souza-
Autor(es): dc.creatorde Oliveira, Gustavo Yudi Orikassa-
Autor(es): dc.creatorRamírez, Paula Camila-
Autor(es): dc.creatorMartinelli, Bruno-
Autor(es): dc.creatorda Silva Alexandre, Tiago-
Autor(es): dc.creatorBorghi-Silva, Audrey-
Autor(es): dc.creatorCiolac, Emmanuel Gomes-
Autor(es): dc.creatorMendes, Renata Gonçalves-
Data de aceite: dc.date.accessioned2025-08-21T21:26:13Z-
Data de disponibilização: dc.date.available2025-08-21T21:26:13Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/oby.23311-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233809-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233809-
Descrição: dc.descriptionObjective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19.-
Descrição: dc.descriptionCardiopulmonary Physiotherapy Laboratory Department of Physical Therapy Federal University of São Carlos-
Descrição: dc.descriptionExercise and Chronic Disease Research Laboratory Department of Physical Education School of Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Therapy Universidad Industrial de Santander-
Descrição: dc.descriptionDepartment of Gerontology Federal University of São Carlos-
Descrição: dc.descriptionDepartment of Physical Therapy Sacred Heart University Center-
Descrição: dc.descriptionExercise and Chronic Disease Research Laboratory Department of Physical Education School of Sciences São Paulo State University-
Formato: dc.format165-171-
Idioma: dc.languageen-
Relação: dc.relationObesity-
???dc.source???: dc.sourceScopus-
Título: dc.titleDeterminants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: A cross-sectional study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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