Effect of resistance training on osteopenic rat bones in neonatal streptozotocin-induced diabetes: Analysis of GLUT4 content and biochemical, biomechanical, densitometric, and microstructural evaluation

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Melo Yamamoto, Aline Pedro-
Autor(es): dc.creatorChiba, Fernando Yamamoto-
Autor(es): dc.creatorAstolphi, Rafael Dias-
Autor(es): dc.creatorde Oliveira da Mota, Max Sander-
Autor(es): dc.creatorLouzada, Mário Jefferson Quirino-
Autor(es): dc.creatorde Lima Coutinho Mattera, Maria Sara-
Autor(es): dc.creatorGarbin, Cléa Adas Saliba-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorTsosura, Thaís Verônica Saori-
Autor(es): dc.creatorBelardi, Bianca Elvira-
Autor(es): dc.creatordos Santos, Rodrigo Martins-
Autor(es): dc.creatorOkamoto, Maristela Mitiko-
Autor(es): dc.creatorMachado, Ubiratan Fabres-
Autor(es): dc.creatorMatsushita, Doris Hissako-
Data de aceite: dc.date.accessioned2025-08-21T22:14:15Z-
Data de disponibilização: dc.date.available2025-08-21T22:14:15Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.120143-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233797-
Descrição: dc.descriptionAims: To investigate the effect of resistance training-RT on glycemia, expression of the glucose transporter-GLUT4, bone mineral density-BMD, and microstructural and biomechanical properties of osteopenic rat bones in neonatal streptozotocin-induced diabetes. Main methods: Sixty-four 5-day-old male rats were divided into two groups: control and diabetic rats injected with vehicle or streptozotocin, respectively. After 55 days, densitometric analysis-DA of the tibia was performed. These groups were subdivided into four subgroups: non-osteopenic control-CN, osteopenic control-OC, non-osteopenic diabetic-DM, and osteopenic diabetic-OD. The OC and OD groups were suspended by their tails for 21 days to promote osteopenia in the hindlimb; subsequently, a second DA was performed. The rats were subdivided into eight subgroups: sedentary control-SC, sedentary osteopenic control-SOC, exercised control-EC, exercised osteopenic control-EOC, sedentary diabetic-SD, sedentary osteopenic diabetic-SOD, exercised diabetic-ED, and exercised osteopenic diabetic-EOD. For RT, the rats climbed a ladder with weights secured to their tails for 12 weeks. After RT, a third DA was performed, and blood samples, muscles, and tibias were assessed to measure glycemia, insulinemia, GLUT4 content, bone maximum strength, fracture energy, extrinsic stiffness, BMD, cancellous bone area, trabecular number, and trabecular width. Key findings: After RT, glycemia, GLUT4 content, BMD, and bone microstructural and biomechanical properties were improved in diabetic rats (osteopenic and non-osteopenic). However, RT had no effect on these parameters in the EC and SC groups. Significance: These results suggest that RT improves GLUT4 content, BMD, and microstructural and biomechanical properties of bone in osteopenic and non-osteopenic diabetic rats and is effective in controlling glycemia.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Physiology and Biophysics São Paulo Institute of Biomedical Sciences USP-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionFAPESP: 2010/14755-5-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone mineral density-
Palavras-chave: dc.subjectDiabetes mellitus-
Palavras-chave: dc.subjectGLUT4-
Palavras-chave: dc.subjectInsulin sensitivity-
Palavras-chave: dc.subjectOsteopenia-
Palavras-chave: dc.subjectResistance training-
Título: dc.titleEffect of resistance training on osteopenic rat bones in neonatal streptozotocin-induced diabetes: Analysis of GLUT4 content and biochemical, biomechanical, densitometric, and microstructural evaluation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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