Systemic treatment of penile squamous cell carcinoma—hurdles and hopes of preclinical models and clinical regimens: a narrative review

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Autor(es): dc.contributorUniversity Medicine Mainz-
Autor(es): dc.contributorUniversity of Southern Denmark-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGoethe University Hospital Frankfurt-
Autor(es): dc.contributorMoffitt Cancer Center-
Autor(es): dc.creatorThomas, Anita-
Autor(es): dc.creatordo Canto Alvim, Luisa Matos-
Autor(es): dc.creatorRainho, Claudia Aparecida-
Autor(es): dc.creatorJuengel, Eva-
Autor(es): dc.creatorBlaheta, Roman Alexander-
Autor(es): dc.creatorSpiess, Philippe E.-
Autor(es): dc.creatorRogatto, Silvia Regina-
Autor(es): dc.creatorTsaur, Igor-
Data de aceite: dc.date.accessioned2025-08-21T21:09:24Z-
Data de disponibilização: dc.date.available2025-08-21T21:09:24Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21037/tau-20-945-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233778-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233778-
Descrição: dc.descriptionDespite contemporary research efforts, the prognosis of penile squamous cell carcinoma (PeSCC) has not significantly improved over the past decade. Despite frequently encountered patient-related delayed medical consultations impairing outcomes, several other aspects contribute to the lack of advancement in the treatment of this condition. One essential reason is that translational research, a prerequisite for the clinically successful disease management, is still at an early stage in PeSCC as compared to many other malignancies. Preclinical experimental models are indispensable for the evaluation of tumor biology and identification of genomic alterations. However, since neither commercial PeSCC cell lines are available nor xenograft models sustainably established, such analyses are challenging in this field of research. In addition, systemic therapies are less effective and toxic without decisive breakthroughs over recent years. Current systemic management of PeSCC is based on protocols that have been investigated in small series of only up to 30 patients. Thus, there is an unmet medical need for new approaches necessitating research efforts to develop more efficacious systemic strategies. This review aims to highlight the current state of knowledge in the molecular alterations involved in the etiology and ensuing steps for cancer progression, existing preclinical models of translational research, clinically relevant systemic protocols, and ongoing clinical trials.-
Descrição: dc.descriptionDepartment of Urology and Pediatric Urology University Medicine Mainz-
Descrição: dc.descriptionDepartment of Clinical Genetics University Hospital of Southern Denmark Vejle Institute of Regional Health Research University of Southern Denmark-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Urology Goethe University Hospital Frankfurt-
Descrição: dc.descriptionDepartment of Genitourinary Oncology Moffitt Cancer Center-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP), Botucatu-
Formato: dc.format4085-4098-
Idioma: dc.languageen-
Relação: dc.relationTranslational Andrology and Urology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCopy number alterations (CNAs)-
Palavras-chave: dc.subjectMutational profiling-
Palavras-chave: dc.subjectPenile squamous cell carcinoma (PeSCC)-
Palavras-chave: dc.subjectTreatment, biomarkers-
Título: dc.titleSystemic treatment of penile squamous cell carcinoma—hurdles and hopes of preclinical models and clinical regimens: a narrative review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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