Multidimensional single-nuclei rna-seq reconstruction of adipose tissue reveals adipocyte plasticity underlying thermogenic response

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorRegional Blood Center of Ribeirão Preto-
Autor(es): dc.contributorIPEC-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Cologne-
Autor(es): dc.contributorBoston University-
Autor(es): dc.contributorUniversity of Mogi das Cruzes-
Autor(es): dc.creatorBiagi, Carlos Alberto Oliveira de-
Autor(es): dc.creatorCury, Sarah Santiloni-
Autor(es): dc.creatorAlves, Cleidson Pádua-
Autor(es): dc.creatorRabhi, Nabil-
Autor(es): dc.creatorSilva, Wilson Araujo-
Autor(es): dc.creatorFarmer, Stephen R.-
Autor(es): dc.creatorCarvalho, Robson Francisco-
Autor(es): dc.creatorBatista, Miguel Luiz-
Data de aceite: dc.date.accessioned2025-08-21T20:16:06Z-
Data de disponibilização: dc.date.available2025-08-21T20:16:06Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells10113073-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233776-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233776-
Descrição: dc.descriptionAdipose tissue has been classified based on its morphology and function as white, brown, or beige/brite. It plays an essential role as a regulator of systemic metabolism through paracrine and endocrine signals. Recently, multiple adipocyte subtypes have been revealed using RNA sequencing technology, going beyond simply defined morphology but also by their cellular origin, adaptation to metabolic stress, and plasticity. Here, we performed an in-depth analysis of publicly available single-nuclei RNAseq from adipose tissue and utilized a workflow template to characterize adipocyte plasticity, heterogeneity, and secretome profiles. The reanalyzed dataset led to the identification of different subtypes of adipocytes including three subpopulations of thermogenic adipocytes, and provided a characterization of distinct transcriptional profiles along the adipocyte trajectory under thermogenic challenges. This study provides a useful resource for further investigations regarding mechanisms related to adipocyte plasticity and trans-differentiation.-
Descrição: dc.descriptionBundesministerium für Bildung und Forschung-
Descrição: dc.descriptionAmerican Historical Association-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionCenter for Cell-Based Therapy (CEPID/FAPESP) National Institute of Science and Technology in Stem Cell and Cell Therapy (INCTC/CNPq) Regional Blood Center of Ribeirão Preto-
Descrição: dc.descriptionInstitute for Cancer Research IPEC-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Translational Genomics Medical Faculty University of Cologne-
Descrição: dc.descriptionDepartment of Biochemistry School of Medicine Boston University-
Descrição: dc.descriptionDepartment of Integrated Biotechnology University of Mogi das Cruzes-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionBundesministerium für Bildung und Forschung: 01ZX1901A-
Descrição: dc.descriptionAmerican Historical Association: 17POST33660875-
Descrição: dc.descriptionCNPq: 311319/2018-1-
Descrição: dc.descriptionCNPq: 311530/2019-2-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: 413326622-
Descrição: dc.descriptionCNPq: 870415/1997-2-
Descrição: dc.descriptionNational Institutes of Health: DK117161-
Descrição: dc.descriptionNational Institutes of Health: DK117163-
Descrição: dc.descriptionNational Institutes of Health: P30-DK-046200-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: SFB1399-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdipocyte subpopulations-
Palavras-chave: dc.subjectCellular compartment prediction-
Palavras-chave: dc.subjectMature adipocyte plasticity-
Palavras-chave: dc.subjectThermogenic treatment-
Palavras-chave: dc.subjectTranscriptional factors-
Título: dc.titleMultidimensional single-nuclei rna-seq reconstruction of adipose tissue reveals adipocyte plasticity underlying thermogenic response-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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