The influence of antineoplastic agents on the peri-implant bone around osseointegrated titanium implants: an in vivo histomorphometric and immunohistochemical study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMatheus, Henrique Rinaldi-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorGusman, David Jonathan Rodrigues-
Autor(es): dc.creatorForin, Luiz Guilherme-
Autor(es): dc.creatorPiovezan, Bianca Rafaeli-
Autor(es): dc.creatorde Almeida, Juliano Milanezi-
Data de aceite: dc.date.accessioned2025-08-21T20:59:20Z-
Data de disponibilização: dc.date.available2025-08-21T20:59:20Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-021-04239-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233725-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233725-
Descrição: dc.descriptionBackground and objective: The interaction between antineoplastic drugs used for treating cancer and non-affected tissues remains poorly assessed and may be critical for maintaining the quality of life for patients during and after treatment. This pre-clinical study evaluated the effects of cisplatin (CIS) and 5-fluorouracil (5-FU) on the peri-implant repair process around osseointegrated titanium implants installed in the tibiae of rats. Material and methods: Were used 90 male rats, randomly divided into three groups (n = 30): physiological saline solution (PSS), CIS, and 5-FU. Titanium implants (4.0 × 2.2 mm) were inserted in both tibiae of all animals at day 0. The animals received either PSS, CIS, or 5-FU at 35 and 37 days. Euthanasia was performed at 50, 65, and 95 days after surgery. Histometric (bone/implant contact [BIC]) and bone area fraction occupancy (% BAFO), histological, and immunohistochemical (for bone morphogenetic protein 2/4 [BMP2/4], Runt-related transcription factor 2 [RUNX2], osteocalcin [OCN], and tartrate-resistant acid phosphatase [TRAP]) analyses were performed. Data were statistically analyzed. Results: Groups CIS and 5-FU presented lower BIC and lower BAFO as compared with PSS in all time points. The imbalance in bone turnover was observed by the lower number of BMP2/4-, RUNX2-, and OCN-positive cells/mm2 and the higher number of TRAP-positive cells/mm in groups CIS and 5-FU as compared with PSS in all time points. Persistent and exacerbated inflammation was observed in groups CIS and 5-FU. Conclusions: Both antineoplastic agents interfered negatively in the bone turnover around osseointegrated titanium implants. Clinical relevance: Closer and more careful follow-up of patients with osseointegrated implants that will undergo chemotherapy with either CIS or 5-FU shall be performed.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery–Periodontics Division São Paulo State University (Unesp), St. José Bonifácio 1193 - Vila Mendonça, SP-
Descrição: dc.descriptionNucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery–Periodontics Division São Paulo State University (Unesp), St. José Bonifácio 1193 - Vila Mendonça, SP-
Descrição: dc.descriptionNucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry São Paulo State University (Unesp), SP-
Descrição: dc.descriptionFAPESP: 2014/11427-8-
Descrição: dc.descriptionFAPESP: 2017/11805-0-
Formato: dc.format2681-2692-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntineoplastic agents-
Palavras-chave: dc.subjectBone implant interface-
Palavras-chave: dc.subjectCisplatin-
Palavras-chave: dc.subjectFluorouracil-
Palavras-chave: dc.subjectOsseointegration-
Título: dc.titleThe influence of antineoplastic agents on the peri-implant bone around osseointegrated titanium implants: an in vivo histomorphometric and immunohistochemical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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