In vivo toxicogenic potential of Salix alba (Salicaceae) bark extract

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Trás-os-Montes and Alto Douro (Utad)-
Autor(es): dc.contributorGenet. Biotech. Animal Veterinary Res. Centre-
Autor(es): dc.creatorMaistro, Edson Luis-
Autor(es): dc.creatorTerrazzas, Peterson Menezes-
Autor(es): dc.creatorSawaya, Alexandra Christinie Helena Frankland-
Autor(es): dc.creatorRosa, Paulo Cesar Pires-
Autor(es): dc.creatorPerazzo, Fábio Ferreira-
Autor(es): dc.creatorde Mascarenhas Gaivão, Isabel O’Neill-
Data de aceite: dc.date.accessioned2025-08-21T21:44:22Z-
Data de disponibilização: dc.date.available2025-08-21T21:44:22Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15287394.2021.1989351-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233724-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233724-
Descrição: dc.descriptionSalix alba (white willow) bark extract is widely used for conditions associated with inflammation, fever, microbial infection or pain. Exposure of human cultured leukocytes to S. alba in vitro noted a genotoxic response. However, data regarding the influence of this bark extract on DNA damage in vivo are lacking. The main goal of this study was to examine the potential of S.alba bark extract to induce DNA damage and chromosome aberrations in an in vivo model using cells obtained from male Swiss albino mice administered the compound orally. The extract was administered by oral gavage daily for 7 days at doses of 500, 1000, or 2000 mg/kg b.w. Genotoxicity analysis was performed using the comet assay on peripheral blood leukocytes, as well as liver, bone marrow, heart, and testicular cells collected 4 hr after the last treatment and the micronucleus (MN) test on bone marrow cells. In essence cells were collected 28 hr after the penultimate treatment Data demonstrated that S. alba bark extract did not induce significant DNA damage in any cell types examined, or clastogenic/aneugenic effects as detected by the MN test at the three tested doses. Under these experimental conditions, evidence indicates that S.alba bark extract did not initiate genotoxic or chromosome aberrations in various mouse cells investigated.-
Descrição: dc.descriptionSpeech and Hearing Therapy Department São Paulo State University - Unesp-
Descrição: dc.descriptionPrograma De Pós-Graduação Em Biologia Geral E Aplicada–São Paulo State University–Unesp Instituto De Biociências-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences University of Campinas-
Descrição: dc.descriptionDepartment of Genetics and Biotechnology and Animal and Veterinary Research Centre (CECAV) University of Trás-os-Montes and Alto Douro (Utad)-
Descrição: dc.descriptionUniversidade De Tras-os-Montes E Alto Douro Escola De Ciencias Agrarias E Veterinarias Genet. Biotech. Animal Veterinary Res. Centre-
Descrição: dc.descriptionSpeech and Hearing Therapy Department São Paulo State University - Unesp-
Descrição: dc.descriptionPrograma De Pós-Graduação Em Biologia Geral E Aplicada–São Paulo State University–Unesp Instituto De Biociências-
Formato: dc.format121-130-
Idioma: dc.languageen-
Relação: dc.relationJournal of Toxicology and Environmental Health - Part A: Current Issues-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectSalicaceae genotoxicity-
Palavras-chave: dc.subjectSalix comet assay-
Palavras-chave: dc.subjectSalix micronucleus test-
Palavras-chave: dc.subjectWhite willow-
Título: dc.titleIn vivo toxicogenic potential of Salix alba (Salicaceae) bark extract-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.