2D quantitative imaging of magnetic nanoparticles by an ac biosusceptometry based scanning approach and inverse problem

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPhysikalisch-Technische Bundesanstalt-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBiasotti, Gabriel Gustavo de Albuquerque-
Autor(es): dc.creatorPróspero, Andre Gonçalves-
Autor(es): dc.creatorAlvarez, Marcelo Dante Tacconi-
Autor(es): dc.creatorLiebl, Maik-
Autor(es): dc.creatorPinto, Leonardo Antonio-
Autor(es): dc.creatorSoares, Guilherme Augusto-
Autor(es): dc.creatorBakuzis, Andris Figueiroa-
Autor(es): dc.creatorBaffa, Oswaldo-
Autor(es): dc.creatorWiekhorst, Frank-
Autor(es): dc.creatorMiranda, José Ricardo de Arruda-
Data de aceite: dc.date.accessioned2025-08-21T22:42:19Z-
Data de disponibilização: dc.date.available2025-08-21T22:42:19Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/s21217063-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233716-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233716-
Descrição: dc.descriptionThe use of magnetic nanoparticles (MNPs) in biomedical applications requires the quantitative knowledge of their quantitative distribution within the body. AC Biosusceptometry (ACB) is a biomagnetic technique recently employed to detect MNPs in vivo by measuring the MNPs response when exposed to an alternate magnetic field. The ACB technique presents some interesting characteristics: non-invasiveness, low operational cost, high portability, and no need for magnetic shielding. ACB conventional methods until now provided only qualitative information about the MNPs’ mapping in small animals. We present a theoretical model and experimentally demonstrate the feasibility of ACB reconstructing 2D quantitative images of MNPs’ distributions. We employed an ACB single-channel scanning approach, measuring at 361 sensor positions, to reconstruct MNPs’ spatial distributions. For this, we established a discrete forward problem and solved the ACB sys-tem’s inverse problem. Thus, we were able to determine the positions and quantities of MNPs in a field of view of 5 × 5 × 1 cm3 with good precision and accuracy. The results show the ACB system’s capabilities to reconstruct the quantitative spatial distribution of MNPs with a spatial resolution better than 1 cm, and a sensitivity of 1.17 mg of MNPs fixed in gypsum. These results show the system’s potential for biomedical application of MNPs in several studies, for example, electrochemical-functionalized MNPs for cancer cell targeting, quantitative sensing, and possibly in vivo imaging.-
Descrição: dc.descriptionHorizon 2020-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft-
Descrição: dc.descriptionBiosciences Institute of Botucatu São Paulo State University-
Descrição: dc.descriptionPhysikalisch-Technische Bundesanstalt, Abbestraße 2–12-
Descrição: dc.descriptionInstitute of Physics Federal University of Goiás-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Letters at Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionBiosciences Institute of Botucatu São Paulo State University-
Descrição: dc.descriptionHorizon 2020: 16NRM04-
Descrição: dc.descriptionFAPESP: 2013/07699-0-
Descrição: dc.descriptionCNPq: 304107-2019-0-
Descrição: dc.descriptionCAPES: 888 81.198748/2018-01-
Descrição: dc.descriptionCAPES: 88887.198747/2018-00-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: KO5321/3-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: TR408/11-
Descrição: dc.descriptionDeutsche Forschungsgemeinschaft: Wi4230/4-1-
Idioma: dc.languageen-
Relação: dc.relationSensors-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAC Biosusceptometry-
Palavras-chave: dc.subjectInverse problem-
Palavras-chave: dc.subjectMagnetic nanoparticles-
Palavras-chave: dc.subjectQuantitative imaging-
Título: dc.title2D quantitative imaging of magnetic nanoparticles by an ac biosusceptometry based scanning approach and inverse problem-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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