Toxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice

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Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversity Center of Grande Dourados-
Autor(es): dc.contributorState University of Mato Grosso Do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.creatorBranquinho, Lidiane Schultz-
Autor(es): dc.creatorVerdan, Maria Helena-
Autor(es): dc.creatordos Santos, Elisangela-
Autor(es): dc.creatorMacorini, Luis Fernando Benitez-
Autor(es): dc.creatorMaris, Rafael Souza-
Autor(es): dc.creatorKuraoka-Oliveira, Angela Midori-
Autor(es): dc.creatorBacha, Flávia Barbieri-
Autor(es): dc.creatorCardoso, Claudia Andrea Lima-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorSilva-Filho, Saulo Euclides-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Data de aceite: dc.date.accessioned2025-08-21T18:49:04Z-
Data de disponibilização: dc.date.available2025-08-21T18:49:04Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01480545.2021.1982638-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233700-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233700-
Descrição: dc.descriptionDoliocarpus dentatus (Dilleniaceae) has been used in folk medicine to treat inflammation and pain; however, studies evaluating its toxicity potential, as well as its effects on anxiety and depression, are scarce. This study investigated the toxicological profile of an ethanolic extract from leaves of D. dentatus (EEDd), and its effects on anxiety and depression models in mice. Male and female mice received either a single dose (500, 1000 or 2000 mg/kg) or repeated doses (75, 150 or 300 mg/kg) of EEDd by oral gavage. During the subacute toxicity assay, behavioral tests were performed on days 4, 14, 21 and 28. No evidence of toxicity was observed in the animals in both acute and subacute tests. However, males treated with the highest dose presented a reduction in the absolute weight of the kidney, an elevation in the AST levels, in addition to an alteration in the urea levels. The treatment did not affect other biochemical parameters, and did not induce any depressive-like behavior. EEDd exhibited low toxicity after single and repeated exposures. Since some analyzed parameters were compromised, further toxicity studies should be carried out.-
Descrição: dc.descriptionFaculty of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionPostgraduate Program in Chemistry Faculty of Exact Sciences and Technology Federal University of Grande Dourados-
Descrição: dc.descriptionFaculty of Health Sciences University Center of Grande Dourados-
Descrição: dc.descriptionFaculty of Exact and Agrarian Sciences University Center of Grande Dourados-
Descrição: dc.descriptionCenter of Studies in Natural Resources State University of Mato Grosso Do Sul-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu UNESP–Paulista State University-
Descrição: dc.descriptionPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu UNESP–Paulista State University-
Idioma: dc.languageen-
Relação: dc.relationDrug and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacute toxicity-
Palavras-chave: dc.subjectanxiety-
Palavras-chave: dc.subjectdepressive-like behavior-
Palavras-chave: dc.subjectDilleniaceae-
Palavras-chave: dc.subjectsubacute toxicity-
Título: dc.titleToxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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