Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Texas at Dallas-
Autor(es): dc.contributorCentro Universitário Sagrado Coração-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorMahmoud, Ramez H.-
Autor(es): dc.creatorBiguetti, Claudia C.-
Autor(es): dc.creatorSimionato, Gustavo B.-
Autor(es): dc.creatorCustódio, Isabela C.-
Autor(es): dc.creatorSilva, Raquel B. P.-
Autor(es): dc.creatorDuarte, Marco A. H.-
Autor(es): dc.creatorFaverani, Leonardo P.-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorFakhouri, Walid D.-
Autor(es): dc.creatorMatsumoto, Mariza A.-
Data de aceite: dc.date.accessioned2025-08-21T20:02:00Z-
Data de disponibilização: dc.date.available2025-08-21T20:02:00Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-98713-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233616-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233616-
Descrição: dc.descriptionThis study investigated the role 5-lypoxigenase (5-LO) on alveolar socket healing in aged female mice treated with zoledronic acid (ZL). Forty 129/Sv female mice (64–68 weeks old), 20 wild type (WT) and 20 5-LO knockout (5LOKO) were equally distributed according to ZL treatment: WT Control, WT ZL, 5LOKO Control, and 5LOKO ZL. ZL groups were treated with an intraperitoneal injection of 250 µg/Kg of ZL, while controls were treated with saline. Treatments were administered once a week, starting four weeks before surgery for tooth extraction and until 7 and 21 days post-surgery. Mice were euthanized for a comprehensive microscopic analysis (microCT, histomorphometry and immunohistochemistry). WT ZL mice presented intense inflammatory infiltrate (7 days), delayed bone formation (21 days), reduced collagenous matrix quality, and a deficiency in Runx-2 + , TRAP + , and macrophages as compared to controls. 5LOKO ZL animals presented decreased number of Runx-2 + cells in comparison to 5LOKO Control at 7 days, but no major changes in bone healing as compared to WT or 5LOKO mice at 21 days. The knockout of 5LO favored intramembranous bone healing in aged female mice, with a direct impact on inflammatory response and bone metabolism on the development of ONJ-like lesions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioengineering University of Texas at Dallas-
Descrição: dc.descriptionDepartment of Health Sciences Centro Universitário Sagrado Coração-
Descrição: dc.descriptionBauru School of Dentistry University of São Paulo FOB-USP-
Descrição: dc.descriptionDepartment of Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCenter for Craniofacial Research University of Texas Health Science Center at Houston School of Dentistry-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: #2018/08913-9-
Descrição: dc.descriptionFAPESP: #2018/19409-0-
Descrição: dc.descriptionFAPESP: #2019/16067-3-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleAlveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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