Identification of possible salivary metabolic biomarkers and altered metabolic pathways in south american patients diagnosed with oral squamous cell carcinoma

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.contributorUniversidade Mogi das Cruzes-
Autor(es): dc.contributorAnhembi Morumbi University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Sá Alves, Mariana-
Autor(es): dc.creatorde Sá Rodrigues, Nayara-
Autor(es): dc.creatorBandeira, Celso Muller-
Autor(es): dc.creatorChagas, José Francisco Sales-
Autor(es): dc.creatorPascoal, Maria Beatriz Nogueira-
Autor(es): dc.creatorNepomuceno, Gabrielle Luana Jimenez Teodoro-
Autor(es): dc.creatorda Silva Martinho, Herculano-
Autor(es): dc.creatorAlves, Mônica Ghislaine Oliveira-
Autor(es): dc.creatorMendes, Maria Anita-
Autor(es): dc.creatorDias, Meriellen-
Autor(es): dc.creatorAlves, Levy Anderson César-
Autor(es): dc.creatorAlmeida, Janete Dias-
Data de aceite: dc.date.accessioned2025-08-21T19:30:47Z-
Data de disponibilização: dc.date.available2025-08-21T19:30:47Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/metabo11100650-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233607-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233607-
Descrição: dc.descriptionOral squamous cell carcinoma (OSCC) represents 90% of oral malignant neoplasms. The search for specific biomarkers for OSCC is a very active field of research contributing to establishing early diagnostic methods and unraveling underlying pathogenic mechanisms. In this work we investigated the salivary metabolites and the metabolic pathways of OSCC aiming find possible biomarkers. Salivary metabolites samples from 27 OSCC patients and 41 control individuals were compared through a gas chromatography coupled to a mass spectrometer (GC-MS) technique. Our results allowed identification of pathways of the malate-aspartate shuttle, the beta-alanine metabolism, and the Warburg effect. The possible salivary biomarkers were identified using the area under receiver-operating curve (AUC) criterion. Twenty-four metabolites were identified with AUC > 0.8. Using the threshold of AUC = 0.9 we find malic acid, maltose, protocatechuic acid, lactose, 2-ketoadipic, and catechol metabolites expressed. We notice that this is the first report of salivary metabolome in South American oral cancer patients, to the best of our knowledge. Our findings regarding these metabolic changes are important in discovering salivary biomarkers of OSCC patients. However, additional work needs to be performed considering larger populations to validate our results.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biosciences and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Head and Neck Surgery Hospital of the Pontifical Catholic University of Campinas-
Descrição: dc.descriptionCentro de Ciências Naturais e Humanas (CCNH) Universidade Federal do ABC, Av. dos Estados, 5001-
Descrição: dc.descriptionSchool of Dentistry Universidade Mogi das Cruzes-
Descrição: dc.descriptionSchool of Medicine Anhembi Morumbi University-
Descrição: dc.descriptionDempster MS Lab Department of Chemical Engineering Polytechnic School University of Sao Paulo-
Descrição: dc.descriptionDepartment of Biosciences and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionFAPESP: 2016/08633-0-
Descrição: dc.descriptionFAPESP: 2021/09168-8-
Descrição: dc.descriptionCNPq: 307718/2019-0-
Idioma: dc.languageen-
Relação: dc.relationMetabolites-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectGC-MS-
Palavras-chave: dc.subjectMass spectrometry-
Palavras-chave: dc.subjectMetabolites-
Palavras-chave: dc.subjectMetabolomics-
Palavras-chave: dc.subjectOral cancer-
Palavras-chave: dc.subjectOral squamous cell carcinoma-
Palavras-chave: dc.subjectSaliva-
Título: dc.titleIdentification of possible salivary metabolic biomarkers and altered metabolic pathways in south american patients diagnosed with oral squamous cell carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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