Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLozano, Ana Flávia Quiarato-
Autor(es): dc.creatorMoura, Mayara Silva-
Autor(es): dc.creatorTavares, Bruna Marques-
Autor(es): dc.creatorKempinas, Wilma De Grava-
Data de aceite: dc.date.accessioned2025-08-21T19:49:52Z-
Data de disponibilização: dc.date.available2025-08-21T19:49:52Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.119960-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233604-
Descrição: dc.descriptionAims: Sertraline (SE) is one of the most prescribed medications for treating gestational depression, anxiety and stress. However, little is known about its effects on nervous-system development in offspring. Therefore, this study investigated the somatic, reflex and neurobehavioral development of rats exposed to SE during pregnancy, associated or not with stress. Main methods: Pregnant Wistar rats were assigned to the following groups (n = 10-8 rats/group): CO - control animals administered filtered water by gavage; SE - animals administered 20 mg/kg SE by gavage; ST - animals subjected to restraining stress and administered filtered water; ST/SE - animals subjected to restraining stress and administered 20 mg/kg SE. The treatment was administered between gestational days (GD) 13 to 20. Somatic and reflex developments were investigated in the male offspring from postnatal day (PND) 1 to 21. The elevated plus maze was performed on PND 25 and 80. The open field and light/dark box test were performed on PND 90 and 100, respectively. Key findings: Body weight reduction and vaginal bleeding were observed in pregnant rats exposed to SE. The male offspring of the SE group showed delay in incisor eruption, fur development and negative geotaxis. In addition, the SE group was less exploratory (anxious personality) compared to the CO and ST groups. Significance: The results obtained in the present study demonstrate that sertraline not only impairs maternal health, but also, associated or not with stress, can compromise the somatic, reflex and neurobehavioral development of male rats.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences-
Descrição: dc.descriptionLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences-
Descrição: dc.descriptionLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 312118/2017-1-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGestational depression-
Palavras-chave: dc.subjectGestational stress-
Palavras-chave: dc.subjectNeurosomatic development-
Palavras-chave: dc.subjectRat-
Palavras-chave: dc.subjectSertraline-
Palavras-chave: dc.subjectVaginal bleeding-
Título: dc.titleExposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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