MLH1, MSH2, MRE11, and XRCC1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorOral Medicine Unit-
Autor(es): dc.contributorMogi das Cruzes-
Autor(es): dc.contributorSantiago de Compostela-
Autor(es): dc.contributorUniversity of Santiago de Compostela-
Autor(es): dc.contributorAnhembi Morumbi University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDonís, Sergio Piñeiro-
Autor(es): dc.creatorGonzález, Alba Pérez-
Autor(es): dc.creatorAlves, Monica Ghislaine Oliveira-
Autor(es): dc.creatorDo Carmo Carvalho, Bruna F.-
Autor(es): dc.creatorFerreira, Camila C.P.-
Autor(es): dc.creatorAlmeida, Janete Dias-
Autor(es): dc.creatorIruegas, Elena Padín-
Autor(es): dc.creatorPetronacci, Cintia M. Chamorro-
Autor(es): dc.creatorPeñaranda, José M. Suárez-
Autor(es): dc.creatorSayáns, Mario Pérez-
Data de aceite: dc.date.accessioned2025-08-21T22:29:55Z-
Data de disponibilização: dc.date.available2025-08-21T22:29:55Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/PAI.0000000000000929-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233567-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233567-
Descrição: dc.descriptionBackground: DNA damage is accumulated in the cells over time as the result of both exogenous and endogenous factors. The objective of this study was to analyze the immunohistochemical expression of the repair proteins in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). Materials and Methods: Paraffin blocks were selected from the archives of the Laboratory of Hospital Clinico Universitario de Santiago de Compostela, Spain. The sample was composed of 16 cases of OL without dysplasia, 14 cases of OL with dysplasia, and 15 cases of OSCC. The patients' clinical data were collected and immunohistochemical analysis was performed for MLH1, MSH2, MRE11, and XRCC1. The data were submitted to the χ2and the Kruskal-Wallis (P≤0.05) tests. Results: MSH2 was overexpressed in OSCC (P=0.020) and was positive in 100% of patients with OL with dysplasia or OSCC (P=0.019). Positivity for MLH1 was significantly associated with comorbidity (P=0.040), especially in patients who presented with 2 or more pathologies (P=0.028). XRCC1 positivity was also associated with comorbidity (P=0.039). No significant associations were found for the MRE11A expression. Although the simultaneous positivity for the 4 markers was observed in presence of comorbidities (P=0.006). Conclusions: This study supports the effect of the overexpression of MSH2 protein in samples of OL with dysplasia and OSCC, most notably in patients who present with comorbidities and negativity for OL without dysplasia.-
Descrição: dc.descriptionOral Medicine Unit-
Descrição: dc.descriptionTechnology Research Center (NPT) Mogi das Cruzes University Mogi das Cruzes, 200 Dr. C ndido Xavier de Almeida Souza Avenue-
Descrição: dc.descriptionDepartment of Pathology Clinical Hospital Santiago de Compostela-
Descrição: dc.descriptionDepartment of Forensic Sciences and Pathology University of Santiago de Compostela-
Descrição: dc.descriptionTranslational Oncology Laboratory Idichus Foundation Santiago de Compostela-
Descrição: dc.descriptionSchool of Medicine Anhembi Morumbi University-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Formato: dc.format613-618-
Idioma: dc.languageen-
Relação: dc.relationApplied Immunohistochemistry and Molecular Morphology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcancer and precancer-
Palavras-chave: dc.subjectDNA repair-
Palavras-chave: dc.subjectimmunopathology-
Palavras-chave: dc.subjectmucosal diseases-
Palavras-chave: dc.subjectoral squamous cell carcinoma-
Título: dc.titleMLH1, MSH2, MRE11, and XRCC1 in Oral Leukoplakia and Oral Squamous Cell Carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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