Annexin A1 Mimetic Peptide Ac2-26 Modulates the Function of Murine Colonic and Human Mast Cells

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Autor(es): dc.contributorOswaldo Cruz Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaceres School of Medicine-
Autor(es): dc.contributorUniversidad Nacional de Córdoba (UNC)-
Autor(es): dc.contributorCEPAM –Unilago-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorOliveira, Marcia Pereira-
Autor(es): dc.creatorPrates, Janesly-
Autor(es): dc.creatorGimenes, Alexandre Dantas-
Autor(es): dc.creatorCorrea, Silvia Graciela-
Autor(es): dc.creatorOliani, Sonia Maria-
Data de aceite: dc.date.accessioned2025-08-21T19:33:48Z-
Data de disponibilização: dc.date.available2025-08-21T19:33:48Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-09-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fimmu.2021.689484-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233566-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233566-
Descrição: dc.descriptionMast cells (MCs) are main effector cells in allergic inflammation and after activation, they release stored (histamine, heparin, proteases) and newly synthesized (lipid mediators and cytokines) substances. In the gastrointestinal tract the largest MC population is located in the lamina propria and submucosa whereas several signals such as the cytokine IL-4, seem to increase the granule content and to stimulate a remarkable expansion of intestinal MCs. The broad range of MC-derived bioactive molecules may explain their involvement in many different allergic disorders of the gastrointestinal tract. Annexin A1 (AnxA1) is a 37 KDa glucocorticoid induced monomeric protein selectively distributed in certain tissues. Its activity can be reproduced by mimetic peptides of the N-terminal portion, such as Ac2-26, that share the same receptor FPR-L1. Although previous reports demonstrated that AnxA1 inhibits MC degranulation in murine models, the effects of exogenous peptide Ac2-26 on intestinal MCs or the biological functions of the Ac2-26/FPR2 system in human MCs have been poorly studied. To determine the effects of Ac2-26 on the function of MCs toward the possibility of AnxA1-based therapeutics, we treated WT and IL-4 knockout mice with peptide Ac2-26, and we examined the spontaneous and compound 48/80 stimulated colonic MC degranulation and cytokine production. Moreover, in vitro, using human mast cell line HMC-1 we demonstrated that exogenous AnxA1 peptide is capable of interfering with the HMC-1 degranulation in a direct pathway through formyl peptide receptors (FPRs). We envisage that our results can provide therapeutic strategies to reduce the release of MC mediators in inflammatory allergic processes.-
Descrição: dc.descriptionLaboratory of Interdisciplinary Medical Research Oswaldo Cruz Institute-
Descrição: dc.descriptionDepartment of Biology Institute of Bioscience Humanities and Exact Science São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Functional Morphology Faceres School of Medicine-
Descrição: dc.descriptionDepartamento de Bioquímica Clinica-Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI - CONICET) - Facultad de Ciencias Quimicas Universidad Nacional de Córdoba (UNC)-
Descrição: dc.descriptionAdvanced Research Center in Medicine CEPAM –Unilago-
Descrição: dc.descriptionFederal University of São Paulo Graduate Program in Structural and Functional Biology Escola Paulista de Medicina (Unifesp-EPM)-
Descrição: dc.descriptionDepartment of Biology Institute of Bioscience Humanities and Exact Science São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectannexin A1-
Palavras-chave: dc.subjectcolon explant culture-
Palavras-chave: dc.subjectcompound 48/80-
Palavras-chave: dc.subjectFPRs-
Palavras-chave: dc.subjecthuman MC line (HMC-1)-
Palavras-chave: dc.subjectIL-4-
Palavras-chave: dc.subjectmast cell (MC)-
Título: dc.titleAnnexin A1 Mimetic Peptide Ac2-26 Modulates the Function of Murine Colonic and Human Mast Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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