Histopathological features of thrombotic microangiopathies in renal biopsies

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital BP – a Beneficência Portuguesa de São Paulo-
Autor(es): dc.creatorNeto, Miguel Ernandes-
Autor(es): dc.creatorSoler, Lucas de Moraes-
Autor(es): dc.creatorVasconcelos, Halita Vieira Gallindo-
Autor(es): dc.creatorDos Santos, Daniela Cristina-
Autor(es): dc.creatorViero, Rosa Marlene-
Autor(es): dc.creatorde Andrade, Luís Gustavo Modelli-
Data de aceite: dc.date.accessioned2025-08-21T17:20:45Z-
Data de disponibilização: dc.date.available2025-08-21T17:20:45Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.15171/JNP.2019.27-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233554-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233554-
Descrição: dc.descriptionBackground: Thrombotic microangiopathy (TMA) is a morphologic lesion characterized by thrombi occluding microvasculature related to endothelial injury. Objectives: This study aimed to assess the association between histopathological findings and etiology of TMA. Patients and Methods: This cross-sectional study comprised a sample of 34 patients who underwent renal biopsy and received an initial TMA diagnoses resulting in 29 definitive TMA cases. We evaluated the TMA features and clinical histopathological correlation. Results: The most frequent etiologies were atypical hemolytic uremic syndrome (aHUS) (n= 10; 34.5%), hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STEC-HUS) (n=6; 24.1%) and secondary causes of TMA (n= 12; 41.4%). We found the following histological features; patients with aHUS had thrombi in 60% of biopsies, membranoproliferative glomerulonephritis (MPGN)-like pattern in 20% and ischemia in 20%; patients with STEC-HUS had thrombi (14.3%), MPGN-like pattern (14.3%), endothelial swelling (14.3%) and ischemia (57.1%); patients with secondary etiologies had thrombi (58.3%), endothelial swelling (16.7%), ischemia (16.7%) and MPGN-like pattern (8.3%). Conclusions: The distribution of classic TMA findings was not related to etiology in spite of micro-thrombi having been found mostly in aHUS and secondary etiologies, whereas ischemia was found mainly in STEC-HUS. We did not find a histopathological pattern to each etiology of TMA.-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionHospital BP – a Beneficência Portuguesa de São Paulo-
Descrição: dc.descriptionDepartment of Pathology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Nephropathology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndothelium-
Palavras-chave: dc.subjectHemolytic uremic syndrome-
Palavras-chave: dc.subjectMicrothrombi-
Palavras-chave: dc.subjectShiga toxin-
Palavras-chave: dc.subjectThrombotic microangiopathy-
Título: dc.titleHistopathological features of thrombotic microangiopathies in renal biopsies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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