Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorSantos, Nilton José-
Autor(es): dc.creatorBarquilha, Caroline Nascimento-
Autor(es): dc.creatorBarbosa, Isabela Correa-
Autor(es): dc.creatorMacedo, Rodrigo Tavares-
Autor(es): dc.creatorLima, Flávio Oliveira-
Autor(es): dc.creatorJustulin, Luis Antônio-
Autor(es): dc.creatorBarbosa, Guilherme Oliveira-
Autor(es): dc.creatorCarvalho, Hernandes F.-
Autor(es): dc.creatorFelisbino, Sérgio Luis-
Data de aceite: dc.date.accessioned2025-08-21T22:50:52Z-
Data de disponibilização: dc.date.available2025-08-21T22:50:52Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-08-12-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms22168669-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233548-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233548-
Descrição: dc.descriptionProstate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new biomarkers are still needed. The expression pattern and protein tissue localization of proteoglycans of the syndecan family (SDC 1-4) and syntenin-1 (SDCBP) were determined in normal and prostatic tumor tissue from two genetically engineered mouse models and human prostate tumors. Studies were validated using SDC 1-4 and SDCBP mRNA levels and patient survival data from The Cancer Genome Atlas and CamCAP databases. RNAseq showed increased expression of Sdc1 in Pb-Cre4/Ptenf/f mouse Pca and upregulation of Sdc3 expression and downregulation of Sdc2 and Sdc4 when compared to the normal prostatic tissue in Pb-Cre4/Trp53f/f-;Rb1f/f mouse tumors. These changes were confirmed by immunohistochemistry. In human PCa, SDC 1-4 and SDCBP immunostaining showed variable localization. Furthermore, Kaplan-Meier analysis showed that patients expressing SDC3 had shorter prostate-specific survival than those without SDC3 expression (log-rank test, p = 0.0047). Analysis of the MSKCC-derived expression showed that SDC1 and SDC3 overexpression is predictive of decreased biochemical recurrence-free survival (p = 0.0099 and p = 0.045, respectively), and SDC4 overexpression is predictive of increased biochemical recurrence-free survival (p = 0.035). SDC4 overexpression was associated with a better prognosis, while SDC1 and SDC3 were associated with more aggressive tumors and a worse prognosis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional BIology Institute of Bioscience of Botucatu (IBB) São Paulo State University-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology (IB) UNICAMP-State University of Campinas-
Descrição: dc.descriptionBotucatu School of Medicine (FMB) São Paulo State University-
Descrição: dc.descriptionDepartment of Structural and Functional BIology Institute of Bioscience of Botucatu (IBB) São Paulo State University-
Descrição: dc.descriptionBotucatu School of Medicine (FMB) São Paulo State University-
Descrição: dc.descriptionFAPESP: 2015/26175-7, 2016/09532-3, 2019/19644-1-
Idioma: dc.languageen-
Relação: dc.relationInternational journal of molecular sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgene expression-
Palavras-chave: dc.subjectoutcome-
Palavras-chave: dc.subjectprognostic marker-
Palavras-chave: dc.subjectprostate cancer-
Palavras-chave: dc.subjectsurvival-
Palavras-chave: dc.subjectsyndecan-
Título: dc.titleSyndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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