Two-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorOregon Health and Science University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGonçalves, Rafael Simões-
Autor(es): dc.creatorScaffa, Polliana Mendes Candia-
Autor(es): dc.creatorShinohara, Mirela Sanae-
Autor(es): dc.creatorde Andrade Carvalho, Paulo Roberto Marão-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Autor(es): dc.creatorFagundes, Ticiane Cestari-
Data de aceite: dc.date.accessioned2025-08-21T18:09:42Z-
Data de disponibilização: dc.date.available2025-08-21T18:09:42Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-021-04166-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233519-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233519-
Descrição: dc.descriptionObjectives: To evaluate different restorative techniques for non-carious cervical lesions (NCCLs) and the activity of matrix metalloproteinases (MMPs) in gingival crevicular fluid. Materials and methods: Two hundred restorations were performed in 50 patients using resin composite restorative system without (I) and with selective enamel conditioning (II) and resin-modified glass-ionomer cement without (III) and with EDTA pretreatment (IV). Gingival crevicular fluid samples were collected in 15 patients. Restorations were evaluated using USPHS criteria at baseline and after 2 years. Percentages of MMP activity were assessed by zymography as a surrogate outcome. Equality tests of two proportions, logistic regression analysis, survival analysis, ANOVA repeated measures, and Fisher tests were used. Results: No differences in clinical performance were found among groups. Group I had lower retention at 2 years than at baseline. Decreased alpha scores for marginal integrity and marginal discoloration were observed for all groups after 2 years. MMP-2 decreased after 1 year, and its activity increased back to the initial level after 2 years, mainly for groups I, II, and III. MMP-9 increased after 1 year, and it was reduced to the initial level after 2 years, mainly for group I. Conclusions: All restorative techniques performed similarly in NCCLs after 2 years with initial marginal defect alterations. MMP-2 reestablished its initial levels after 2 years, and MMP-9 had few alterations over time in crevicular fluid. Clinical relevance The different restorative techniques are equally successful in NCCLs after 2 years of clinical functioning and have similar effects on MMPs present in crevicular fluid.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionAraçatuba School of Dentistry São Paulo State University, José Bonifácio St, 1193, SP-
Descrição: dc.descriptionOregon Health and Science University, SW Sam Jackson Park Rd, OR 97239-
Descrição: dc.descriptionBauru School of Dentistry University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla St., 9-75 - Jardim Brasil, SP-
Descrição: dc.descriptionAraçatuba School of Dentistry São Paulo State University, José Bonifácio St, 1193, SP-
Descrição: dc.descriptionFAPESP: 2014/07086-0-
Descrição: dc.descriptionCNPq: 447616/2014-5-
Formato: dc.format1889-1902-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectClinical trial-
Palavras-chave: dc.subjectGingival crevicular fluid-
Palavras-chave: dc.subjectGlass-ionomer cement-
Palavras-chave: dc.subjectMatrix metalloproteinases-
Palavras-chave: dc.subjectNon-carious cervical lesions-
Palavras-chave: dc.subjectResin composite-
Título: dc.titleTwo-year randomized clinical trial of different restorative techniques in non-carious cervical lesions and MMP activity in gingival crevicular fluid-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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