Therapeutic effect of Curcuma longa L. on the nonalcoholic fatty liver disease (NAFLD) physiopathology due fructose consumption

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorHasimoto, Fabiana Kurokawa-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini-
Autor(es): dc.creatorCosta, Mariane Róvero-
Autor(es): dc.creatorde Souza, Marajane Bruno-
Autor(es): dc.creatorAun, Aline Garcia-
Autor(es): dc.creatorNogueira, Flávia Ribeiro-
Autor(es): dc.creatorAlves, Pedro Henrique Rizzi-
Autor(es): dc.creatorLima, Giuseppina Pace Pereira-
Autor(es): dc.creatorGarcia, Jéssica Leite-
Autor(es): dc.creatorde Almeida Silva, Carol Cristina Vágula-
Autor(es): dc.creatorFerron, Artur Junio Togneri-
Autor(es): dc.creatorMinatel, Igor Otávio-
Autor(es): dc.creatorMoreto, Fernando-
Autor(es): dc.creatorBraz, Mariana Gobbo-
Autor(es): dc.creatorCorrêa, Camila Renata-
Data de aceite: dc.date.accessioned2025-08-21T18:51:25Z-
Data de disponibilização: dc.date.available2025-08-21T18:51:25Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s41110-020-00127-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233504-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233504-
Descrição: dc.descriptionPurpose: The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammation, and oxidative stress. Curcuma longa L. is a member of the Zingiberaceae family and has traditionally been used as a medicinal herb. The aim was to verify the therapeutic effect of Curcuma longa L. in the physiopathology of NAFLD due to the fructose consumption. Methods: During 16 weeks, animals (n = 12) received standard chow + fructose in drinking water (30%) ad libitum. After, animals were randomly allocated to receive placebo treatment (fructose, n = 6) or Curcuma longa L. treatment (fructose + Cl, n = 6) for further 8 weeks. Both groups continued receiving standard chow + fructose in drinking water (30%) ad libitum. Results: Curcuma longa L. was effective to reduce insulin resistance and triglycerides levels, increase PPAR-α protein expression in liver, and attenuate macrovesicular steatosis, liver IL-6 levels, and oxidative stress (with lower protein carbonylation, MDA, and DNA damage and increase in SOD and catalase antioxidant enzymes) induced by fructose consumption. Conclusion: Curcuma longa L. treatment was effective to modulate the physiopathology of NAFLD due to fructose consumption.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Bairro: Distrito de Rubião Junior-
Descrição: dc.descriptionInstitute of Bioscience São Paulo State University (UNESP)-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Bairro: Distrito de Rubião Junior-
Descrição: dc.descriptionInstitute of Bioscience São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/18461-2-
Idioma: dc.languageen-
Relação: dc.relationNutrire-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectCurcumin-
Palavras-chave: dc.subjectLiver-
Palavras-chave: dc.subjectPolyphenols-
Título: dc.titleTherapeutic effect of Curcuma longa L. on the nonalcoholic fatty liver disease (NAFLD) physiopathology due fructose consumption-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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