Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Abc-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Sorocaba (UNISO)-
Autor(es): dc.contributorThe University of British Columbia-
Autor(es): dc.creatorCampos, Estefânia V. R.-
Autor(es): dc.creatorProença, Patricia L. F.-
Autor(es): dc.creatorCosta, Tais Germano Da-
Autor(es): dc.creatorDe Lima, Renata-
Autor(es): dc.creatorHedtrich, Sarah-
Autor(es): dc.creatorFraceto, Leonardo Fernandes-
Autor(es): dc.creatorDe Araujo, Daniele Ribeiro-
Data de aceite: dc.date.accessioned2025-08-21T21:35:57Z-
Data de disponibilização: dc.date.available2025-08-21T21:35:57Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-09-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsapm.1c00021-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233466-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233466-
Descrição: dc.descriptionAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Topical corticosteroids are the first-line treatment to control moderate-to-severe AD; however, prolonged application of corticosteroids is required, which can result in dermal atrophy as a side effect. Drug-delivery systems can provide more effective and targeted therapy strategies. In this study, budesonide (BUD) was encapsulated into chitosan (CS)-coated PLGA nanoparticles, which were further incorporated into poloxamer hydrogels to improve the anti-inflammatory activity and decrease adverse effects. The nanoparticles were prepared by the emulsification-solvent evaporation technique, and their physicochemical characteristics were evaluated. Rheological properties of the hydrogels, such as viscosity and sol-gel transition temperature, were evaluated with and without nanoparticles. In vitro release kinetics and ex vivo drug absorption studies were performed using Franz diffusion cells. The nanoparticles showed a mean diameter of 324 ± 4 nm, positive ζ potential (20 mV) due to CS coating, and high encapsulation efficiency (>90%). The nanoparticles did not show cytotoxic effects in primary human fibroblasts and keratinocytes; however, all formulations induced the generation of reactive oxygen species. Both nanoparticles and hydrogels were able to change the release kinetics of BUD when compared to the nonencapsulated compound. Nanoparticles were not able to surmount the stratum corneum of excised human skin, but the nanoencapsulation facilitated the skin absorption of BUD. The hydrogels containing nanoparticles or not showed non-Newtonian and pseudoplastic behavior. The nanoformulations seem to be a good candidate to deliver glucocorticoids in the skin of AD patients.-
Descrição: dc.descriptionHuman and Natural Sciences Center Federal University of Abc, Sao Paulo-
Descrição: dc.descriptionDrugs and Bioactives Delivery Systems Research Group - Sislibio Federal University of Abc, Sao Paulo-
Descrição: dc.descriptionDepartment of Environmental Engineering Institute of Science and Technology Sao Paulo State University - Unesp, Sao Paulo-
Descrição: dc.descriptionLaboratory for Evaluation of the Bioactivity and Toxicology of Nanomaterials University of Sorocaba (UNISO), Sao Paulo-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences The University of British Columbia-
Descrição: dc.descriptionDepartment of Environmental Engineering Institute of Science and Technology Sao Paulo State University - Unesp, Sao Paulo-
Formato: dc.format4436-4449-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Polymer Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectatopic dermatitis-
Palavras-chave: dc.subjectbudesonide-
Palavras-chave: dc.subjectpolymeric nanoparticles-
Palavras-chave: dc.subjectthermoresponsive hydrogels-
Palavras-chave: dc.subjecttopical release-
Título: dc.titleHydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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