Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorDelello Di Filippo, Leonardo-
Autor(es): dc.creatorHofstätter Azambuja, Juliana-
Autor(es): dc.creatorPaes Dutra, Jessyca Aparecida-
Autor(es): dc.creatorTavares Luiz, Marcela-
Autor(es): dc.creatorLobato Duarte, Jonatas-
Autor(es): dc.creatorNicoleti, Luiza Ribeiro-
Autor(es): dc.creatorOlalla Saad, Sara Teresinha-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T16:57:45Z-
Data de disponibilização: dc.date.available2025-08-21T16:57:45Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ejpb.2021.08.011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233458-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233458-
Descrição: dc.descriptionGlioblastoma multiforme (GBM) is the most common primary brain cancer. GBM has aggressive development, and the pharmacological treatment remains a challenge due to GBM anatomical characteristics’ (the blood–brain barrier and tumor microenvironment) and the increasing resistance to marketed drugs, such as temozolomide (TMZ), the first-line drug for GBM treatment. Due to physical–chemical properties such as short half-life time and the increasing resistance shown by GBM cells, high doses and repeated administrations are necessary, leading to significant adverse events. This review will discuss the main molecular mechanisms of TMZ resistance and the use of functionalized nanocarriers as an efficient and safe strategy for TMZ delivery. GBM-targeting nanocarriers are an important tool for the treatment of GBM, demonstrating to improve the biopharmaceutical properties of TMZ and repurpose its use in anti-GBM therapy. Technical aspects of nanocarriers will be discussed, and biological models highlighting the advantages and effects of functionalization strategies in TMZ anti-GBM activity. Finally, conclusions regarding the main findings will be made in the context of new perspectives for the treatment of GBM using TMZ as a chemotherapy agent, improving the sensibility and biological anti-tumor effect of TMZ through functionalization strategies.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionHematology and Transfusion Medicine Center University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Formato: dc.format76-89-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Pharmaceutics and Biopharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrain cancer-
Palavras-chave: dc.subjectCancer therapy-
Palavras-chave: dc.subjectDrug resistance-
Palavras-chave: dc.subjectFunctionalization-
Palavras-chave: dc.subjectGlioblastoma-
Palavras-chave: dc.subjectNanotechnology-
Título: dc.titleImproving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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