Production of l (+) lactic acid by lactobacillus casei ke11: Fed batch fermentation strategies

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Paola Monteiro-
Autor(es): dc.creatorSantos, Larissa Provasi-
Autor(es): dc.creatorCoelho, Luciana Fontes-
Autor(es): dc.creatorAvila Neto, Paulo Marcelo-
Autor(es): dc.creatorSass, Daiane Cristina-
Autor(es): dc.creatorContiero, Jonas-
Data de aceite: dc.date.accessioned2025-08-21T17:27:11Z-
Data de disponibilização: dc.date.available2025-08-21T17:27:11Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/fermentation7030151-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233414-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233414-
Descrição: dc.descriptionLactic acid and its derivatives are widely used in pharmaceutical, leather, textile and food industries. However, until now there have been few systematic reports on fed-batch fermentation for efficient production and high concentration of l-lactic acid by lactic acid bacteria. This study describes the obtainment of L (+) lactic acid from sucrose using the Lactobacillus casei Ke11 strain through different feeding strategies using an accessible pH neutralizer such as CaCO3 . The exponential feeding strategy can increase lactic acid production and productivity (175.84 g/L and 3.74 g/L/h, respectively) with a 95% yield, avoiding inhibition by high initial substrate concentration and, combined with the selected agent controller, avoids the cellular stress that could be caused by the high osmotic pressure of the culture media. The purification of the acid using charcoal and celite, followed by the use of a cation exchange column proved to be highly efficient, allowing a high yield of lactic acid, high removal of sugars and proteins. The described process shows great potential for the production of lactic acid, as well as the simple, efficient and low-cost purification method. This way, this work is useful to the large-scale fermentation of L. casei Ke11 for production of l-lactic acid.-
Descrição: dc.descriptionInstitute of Biociences São Paulo State University (Unesp)-
Descrição: dc.descriptionInstitute for Research in Bioenergy São Paulo State University (Unesp)-
Descrição: dc.descriptionInstitute of Biociences São Paulo State University (Unesp)-
Descrição: dc.descriptionInstitute for Research in Bioenergy São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationFermentation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFed batch fermentation-
Palavras-chave: dc.subjectFermentation strategies-
Palavras-chave: dc.subjectL (+) lactic acid-
Palavras-chave: dc.subjectLactic acid extraction-
Palavras-chave: dc.subjectLactobacillus casei Ke11-
Título: dc.titleProduction of l (+) lactic acid by lactobacillus casei ke11: Fed batch fermentation strategies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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