Relationship between innate immune response toll-like receptor 4 (Tlr-4) and the pathophysiological process of obesity cardiomyopathy

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso-
Autor(es): dc.creatorRizzi Alves, Pedro Henrique-
Autor(es): dc.creatorTogneri Ferron, Artur Junio-
Autor(es): dc.creatorCosta, Mariane Róvero-
Autor(es): dc.creatorHasimoto, Fabiana Kurokawa-
Autor(es): dc.creatorGregolin, Cristina Schmitt-
Autor(es): dc.creatorGarcia, Jéssica Leite-
Autor(es): dc.creatorDe Campos, Dijon Henrique Salomé-
Autor(es): dc.creatorCicogna, Antônio Carlos-
Autor(es): dc.creatorDe Mattei, Letícia-
Autor(es): dc.creatorMoreto, Fernando-
Autor(es): dc.creatorZanati Bazan, Silméia Garcia-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini-
Autor(es): dc.creatorCorrêa, Camila Renata-
Data de aceite: dc.date.accessioned2025-08-21T21:13:19Z-
Data de disponibilização: dc.date.available2025-08-21T21:13:19Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.36660/abc.20190788-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233402-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233402-
Descrição: dc.descriptionBackground: Obesity is a chronic low-grade inflammation condition related to cardiac disorders. However, the mechanism responsible for obesity-related cardiac inflammation is unclear. The toll-like receptor 4 (TLR-4) belongs to a receptor of the transmembrane family responsible for the immune response whose activation stimulates the production of proinflammatory cytokines. Objective: To test whether the activation of the TLR-4 receptor participates in the obesity cardiomyopathy process, due to cytokine production through NF-ĸB activation. Methods: Male Wistar rats were randomized into two groups: The control group (C, n= 8 animals) that received standard diet/water and the obese group (OB, n= 8 animals) that were fed a high sugar-fat diet and water plus 25% of sucrose for 30 weeks. Nutritional analysis: Body weight, adiposity index, food, water, and caloric intake. Obesity-related disorders analysis: Plasma glucose, uric acid and triglycerides, HOMA-IR, systolic blood pressure, TNF-α in adipose tissue. Cardiac analysis included: TLR-4 and NF-ĸB protein expression, TNF-α and IL-6 levels. Comparison by unpaired Student’s t-test or Mann- Whitney test with a p-value < 0.05 as statistically significant. Results: The OB group showed obesity, high glucose, triglycerides, uric acid, HOMA, systolic blood pressure, and TNF-α in adipose tissue. OB group presented cardiac remodeling and diastolic dysfunction. TLR-4 and NF-ĸB expression and cytokine levels were higher in OB. Conclusion: Our findings conclude that, in an obesogenic condition, the inflammation derived from cardiac TLR-4 activation can be a mechanism able to lead to remodeling and cardiac dysfunction.-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina-
Descrição: dc.descriptionUniversidade Federal de Mato Grosso-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina-
Formato: dc.format91-99-
Idioma: dc.languageen-
Relação: dc.relationArquivos Brasileiros de Cardiologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdipocytes-
Palavras-chave: dc.subjectCardiovascular Diseases/physiopathology-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectFatty Acid synthases-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNutrional Assessment-
Palavras-chave: dc.subjectObesity-
Título: dc.titleRelationship between innate immune response toll-like receptor 4 (Tlr-4) and the pathophysiological process of obesity cardiomyopathy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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