Two Novel Mutations Associated with Polymyxin-B Resistance in a Pandemic Lineage of Uropathogenic Escherichia coli of the Sequence Type 69

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto Adolfo Lutz-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorDos Santos, Carla Adriana-
Autor(es): dc.creatorHernandes, Rodrigo Tavanelli-
Autor(es): dc.creatorCunha, Marcos Paulo Vieira-
Autor(es): dc.creatorNagamori, Filipe Onishi-
Autor(es): dc.creatorGonçalves, Claudia Regina-
Autor(es): dc.creatorSacchi, Claudio Tavares-
Autor(es): dc.creatorTiba-Casas, Monique Ribeiro-
Autor(es): dc.creatorCamargo, Carlos Henrique-
Data de aceite: dc.date.accessioned2025-08-21T19:48:08Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:08Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1159/000517817-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233382-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233382-
Descrição: dc.descriptionBackground: Uropathogenic Escherichia coli (UPEC) are frequent pathogens worldwide, impacting on the morbidity and economic costs associated with antimicrobial treatment. Objectives: We report two novel mutations associated with polymyxin-B resistance in an UPEC isolate collected in 2019. Methods: Isolate was submitted to antimicrobial susceptibility testing including broth microdilution for polymyxin B. Whole genome was sequenced and analyzed. Results: Polymyxin-B total inhibition occurred at 16 mg/L (resistant). UPEC isolate was assigned to the phylogroup D, serotype O117:H4, and Sequence Type 69. mcr genes were not detected, but two novel mutations in the pmrA/basS (A80S) and pmrB/basR (D149N) genes were identified. Conclusions: The occurrence of non-mcr polymyxin resistance in E. coli from extraintestinal infections underscores the need of a continuous surveillance of this evolving pathogen.-
Descrição: dc.descriptionInstituto Adolfo Lutz-
Descrição: dc.descriptionInstituto de Biociências de Botucatu Universidade Estadual Paulista júlio de Mesquita Filho-
Descrição: dc.descriptionFaculdade de Medicina Veterinária e Zootecnia Universidade de São Paulo-
Descrição: dc.descriptionInstituto de Biociências de Botucatu Universidade Estadual Paulista júlio de Mesquita Filho-
Formato: dc.format92-98-
Idioma: dc.languageen-
Relação: dc.relationChemotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial resistance-
Palavras-chave: dc.subjectEscherichia coli-
Palavras-chave: dc.subjectPolymyxin B-
Palavras-chave: dc.subjectUropathogenic Escherichia coli-
Palavras-chave: dc.subjectWhole-genome sequencing-
Título: dc.titleTwo Novel Mutations Associated with Polymyxin-B Resistance in a Pandemic Lineage of Uropathogenic Escherichia coli of the Sequence Type 69-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.