Propolis increases Foxp3 expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorApis Flora Indl. Coml. Ltda.-
Autor(es): dc.creatorConte, Fernanda Lopes-
Autor(es): dc.creatorTasca, Karen Ingrid-
Autor(es): dc.creatorSantiago, Karina Basso-
Autor(es): dc.creatorde Oliveira Cardoso, Eliza-
Autor(es): dc.creatorRomagnoli, Graziela Gorete-
Autor(es): dc.creatorde Assis Golim, Marjorie-
Autor(es): dc.creatorBraz, Aline Márcia Marques-
Autor(es): dc.creatorBerretta, Andresa Aparecida-
Autor(es): dc.creatordo Rosário de Souza, Lenice-
Autor(es): dc.creatorSforcin, José Maurício-
Data de aceite: dc.date.accessioned2025-08-21T22:13:42Z-
Data de disponibilização: dc.date.available2025-08-21T22:13:42Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2021.111984-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233354-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233354-
Descrição: dc.descriptionHIV infection and the prolonged use of antiretroviral therapy (ART) contribute to persistent inflammation and immune deregulation in people living with HIV/AIDS (PLWHA). Propolis is a bee product with plenty of biological properties, including immunomodulatory and anti-inflammatory action. This work aimed to evaluate possible changes in the immune/inflammatory response in PLWHA under ART after propolis intake. Asymptomatic PLWHA were double-blindly randomized into parallel groups receiving propolis (500 mg/day, n = 20) for 3 months or placebo (n = 20). Plasma cytokines (TNF-α, IL-2, IL-4, IL-6, IL-10 and IL17) were evaluated by cytometric bead array; cytokine production by PBMC (IFN-γ, IL-5, IL-17, IL-10, IL-1β, IL-18, and IL-33) was assessed by ELISA; gene expression (T-bet, GATA-3, RORγt and Foxp3) was determined by RT-qPCR, and cell proliferation was analysed by flow cytometry using CFSE staining. The average of gender, age, CD4+/CD8+ T cell count, time of diagnosis and treatment were similar in both groups. No differences were observed in cytokine levels nor in inflammasome activation. However, Pearson's correlation showed that IL-10 was directly correlated to CD4+ T cell count and inversely to IFN-γ after treatment with propolis. Foxp3 expression and lymphocyte proliferation increased in the propolis group. Data suggested that daily propolis consumption may improve the immune response and decrease the inflammatory status in asymptomatic PLWHA under ART.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences, Campus Botucatu-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School, Campus Botucatu-
Descrição: dc.descriptionResearch Development & Innovation Laboratory Apis Flora Indl. Coml. Ltda.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences, Campus Botucatu-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School, Campus Botucatu-
Descrição: dc.descriptionCNPq: 140245/2017-0-
Descrição: dc.descriptionCNPq: 302230/2017-3-
Idioma: dc.languageen-
Relação: dc.relationBiomedicine and Pharmacotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiretroviral therapy-
Palavras-chave: dc.subjectHIV/AIDS-
Palavras-chave: dc.subjectImmunomodulation-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPropolis-
Palavras-chave: dc.subjectTreg cells-
Título: dc.titlePropolis increases Foxp3 expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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