Rare-earth complexes with anti-inflammatory drug sulindac: Synthesis, characterization, spectroscopic and in vitro biological studies

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine-
Autor(es): dc.contributorUniversity of Ottawa-
Autor(es): dc.creatorBarrach Guerra, Renan-
Autor(es): dc.creatorAlves Gálico, Diogo-
Autor(es): dc.creatorFernanda de Campos Fraga-Silva, Thais-
Autor(es): dc.creatorAguiar, Julia-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorBannach, Gilbert-
Data de aceite: dc.date.accessioned2025-08-21T21:42:46Z-
Data de disponibilização: dc.date.available2025-08-21T21:42:46Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ica.2021.120516-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233351-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233351-
Descrição: dc.descriptionNew rare-earth complexes with the general formula [LnIII(sul)3]∙nH2O, where sul− is the anti-inflammatory drug sulindac and Ln3+ = Ce3+, Pr3+, Gd3+, Tb3+, and Ho3+, were synthesized, characterized, and had their cytotoxic activity and anti-inflammatory profile assessed. Characterization employing elemental analysis, thermogravimetry, complexometric titration using EDTA, and differential scanning calorimetry provided the complexes stoichiometric ratio, whereas FTIR data results suggest that the carboxylate groups of sulindac molecules are coordinated to the lanthanide ions in a bidentate chelate fashion, with no sulfinyl groups (S[dbnd]O) coordinated to the metal centers. Diffuse reflectance spectroscopy was employed in order to study the electronic properties of the synthesized complexes, revealing the presence of a metal-to-ligand charge-transfer on the Ce3+ complex. Additionally, cell viability and anti-inflammatory activities of the [Ln(sul)3]∙nH2O compounds were studied employing human peripheral blood mononuclear cells (PBMC), and the results indicated that the treatment with [Ce(sul)3]∙4H2O significantly increased the PMBC viability at lower concentrations, and [Gd(sul)3]∙3H2O and [Ho(sul)3]∙3H2O displayed a high production of H2O2 was observed without a decrease in cell viability.-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Chemistry Department-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Biological Sciences Department-
Descrição: dc.descriptionFederal University of Mato Grosso do Sul School of Medicine-
Descrição: dc.descriptionDepartment of Chemistry and Biomolecular Sciences University of Ottawa-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Chemistry Department-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Biological Sciences Department-
Idioma: dc.languageen-
Relação: dc.relationInorganica Chimica Acta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectIn vitro-
Palavras-chave: dc.subjectLanthanides(III)-
Palavras-chave: dc.subjectMetallodrug-
Palavras-chave: dc.subjectRare-earth-
Palavras-chave: dc.subjectSpectroscopic study-
Palavras-chave: dc.subjectSulindac-
Título: dc.titleRare-earth complexes with anti-inflammatory drug sulindac: Synthesis, characterization, spectroscopic and in vitro biological studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.