Antibiofilm action of Persea americana glycolic extract over Acinetobacter baumannii and absence of toxicity in Galleria mellonella

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDos Santos Liberato, Sabrina Ferreira-
Autor(es): dc.creatorDa Cruz Vegian, Mariana Raquel-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatorDe Alvarenga, Janaína Araújo-
Autor(es): dc.creatorDos Santos, Juliana Guimarães-
Autor(es): dc.creatorTini, Ítalo Rigotti Pereira-
Autor(es): dc.creatorAmêndola, Isabela-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorDe Oliveira, Luciane Dias-
Data de aceite: dc.date.accessioned2025-08-21T16:21:27Z-
Data de disponibilização: dc.date.available2025-08-21T16:21:27Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1515/jcim-2021-0051-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233345-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233345-
Descrição: dc.descriptionThis study aimed to evaluate the antibiofilm activity and toxicity of the glycolic extract of Persea americana P. americanaover multidrug-resistant strains of Acinetobacter baumannii A. baumanniias alternative therapy to be investigated. A bacterial inoculum of each bacterial strain (4a, 5a, 9a, 12a, ATCC 19606) of A. baumannii was prepared and adjusted by the spectrophotometer. The microdilution broth method was performed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). P. americana glycolic extracts were obtained of the tree stalk and leaves. The biofilm viability was tested by MTT assay after 5 min exposure. The toxicity of the extracts was tested by invertebrate model Galleria mellonella. The data were analyzed by ANOVA, Tukey test and log-rank method (α=0.05). The extract showed an inhibitory and bactericidal action over all the tested strains with the lowest MIC value observed for the reference strain (3.12 mg/mL). The extract did not demonstrate toxicity in any of the tested concentrations (12.5, 25 and 50 mg/mL) in Galleria mellonella larvae, with a survival percentage above 80% after 168 h. The glycolic extract of P. americana has microbicidal and antibiofilm activity on multidrug-resistant clinical strains of A. baumannii and showed low toxicity for the invertebrate model G. mellonella.-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology Saõ Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology Saõ Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology Saõ Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology Saõ Paulo State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Complementary and Integrative Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcinetobacter baumannii-
Palavras-chave: dc.subjectantibacterial agents-
Palavras-chave: dc.subjectPersea americana-
Palavras-chave: dc.subjectphytotherapy-
Título: dc.titleAntibiofilm action of Persea americana glycolic extract over Acinetobacter baumannii and absence of toxicity in Galleria mellonella-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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