5-HT3 receptor within the amygdaloid complex modulates pain hypersensitivity induced by empathy model of cohabitation with a partner in chronic pain condition in mice

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNeuroscience and Behavior Institute - IneC-
Autor(es): dc.creatorRodrigues Tavares, Lígia Renata-
Autor(es): dc.creatorPelarin, Vinícius-
Autor(es): dc.creatorBaptista-de-Souza, Daniela-
Autor(es): dc.creatorPereira Ferrari, Daniele-
Autor(es): dc.creatorNunes-de-Souza, Ricardo Luiz-
Autor(es): dc.creatorCanto-de-Souza, Azair-
Data de aceite: dc.date.accessioned2025-08-21T15:21:36Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:36Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/17470919.2021.1954083-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233303-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233303-
Descrição: dc.descriptionCohabitation with a partner undergoing chronic pain induces pain hypersensitivity. Among a lot of other neurochemical pathways, the serotonin (5-HT) role, specifically the 5-HT3 receptor (5-HT3R), in the amygdala has never been evaluated in this model. Here we studied the effects of the amygdala’s chemical inhibition, its neuronal activation pattern, and 5-HT, 5-HIAA, and 5-HT turnover within the amygdala. Furthermore, the systemic and intra-amygdala 5-HT3R activation and blockade in mice that cohabited with a conspecific subjected to chronic constriction injury were investigated. Male Swiss mice were housed in partners for 28 days. The dyads were divided into two groups on the 14th day: cagemate nerve constriction (CNC) and cagemate sham (CS). On the 24th day, cagemates underwent a stereotaxic surgery (when necessary) and, on the 28th day, they were evaluated on the writhing test. The amygdala inactivation promotes pain-hypersensitivity behaviors in groups and dyads; cohabitation with a partner with chronic pain did not change FosB-labeled cells in the amygdala’s nucleus and increases 5-HT turnover in cagemates. Systemic and intra-amygdala 5-HT3R activation attenuated and enhanced the number of writhes, respectively. In contrast, 5-HT3R blockade reduced hypersensitivity pain response. Results suggest the involvement of amygdala serotonergic signaling via 5-HT3R in empathy-like behavior.-
Descrição: dc.descriptionPsychobiology Group Department of Psychology/CECH Universidade Federal de São Carlos - UFSCar-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences UFSCar/UNESP-
Descrição: dc.descriptionLab. Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista - UNESP-
Descrição: dc.descriptionNeuroscience and Behavior Institute - IneC-
Descrição: dc.descriptionProgram in Psychology UFSCar-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences UFSCar/UNESP-
Descrição: dc.descriptionLab. Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista - UNESP-
Formato: dc.format534-548-
Idioma: dc.languageen-
Relação: dc.relationSocial Neuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject5-HT3 receptors-
Palavras-chave: dc.subjectamygdala-
Palavras-chave: dc.subjectEmpathy-
Palavras-chave: dc.subjectpain hypersensitivity 22 July 2021-
Palavras-chave: dc.subjectserotonin-
Título: dc.title5-HT3 receptor within the amygdaloid complex modulates pain hypersensitivity induced by empathy model of cohabitation with a partner in chronic pain condition in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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