Potential effect of hyaluronic acid and triamcinolone acetate, alone or combined, on chondrogenic differentiation of mesenchymal stem cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorResearch Group in Veterinary Pathology-
Autor(es): dc.creatorOcampo, Pablo E.-
Autor(es): dc.creatorVallejo, Viviana-
Autor(es): dc.creatorMontoya, Luis M.-
Autor(es): dc.creatorRocha, Noeme S.-
Autor(es): dc.creatorLandim, Fernanda da C.-
Autor(es): dc.creatorRahal, Sheila C.-
Data de aceite: dc.date.accessioned2025-08-21T17:56:00Z-
Data de disponibilização: dc.date.available2025-08-21T17:56:00Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.17533/udea.rccp.v34n3a06-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233265-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233265-
Descrição: dc.descriptionBackground: Osteoarthritis is a complex degenerative disease with several factors contributing to joint damage. Objective: To compare the potential effect of hyaluronic acid (HA) and triamcinolone acetonide (TA), alone or combined, on the in vitro chondrogenic differentiation process of mesenchymal stem cells (MSCs). Methods: MSCs were divided into four groups: Control, HA, TA, and HA/TA combined. Each treatment group was cultured for 14 days in chondrogenic differentiation medium. The chondrogenic differentiation potential was assessed by histology and immunohistochemistry. Results: The HA and HA/TA-treated MSCs presented histological characteristics similar to native chondrocytes. The extracellular matrix (ECM) of TA-treated MSCs was compact and organized. Glycosaminoglycan staining was intense in Control, moderate in TA, slight in HA/TA, and undetectable in HA. Type II collagen immunoreactivity was high in the TA-treated ECM and MSCs. Conclusions: Histological analysis shows that HA influences morphological development similar to chondrocytes of the MSCs, but with low expression of specific cartilage molecules. The TA promotes formation of a compact and organized ECM.-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Veterinary Medicine and Animal Science-
Descrição: dc.descriptionFaculty of Veterinary Medicine Universidad Nacional de Colombia Research Group in Veterinary Pathology-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Veterinary Medicine and Animal Science-
Formato: dc.format212-223-
Idioma: dc.languageen-
Relação: dc.relationRevista Colombiana de Ciencias Pecuarias-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCartilage-
Palavras-chave: dc.subjectCell differentiation-
Palavras-chave: dc.subjectChondrocytes-
Palavras-chave: dc.subjectChondrogenesis-
Palavras-chave: dc.subjectChondrogenic differentiation-
Palavras-chave: dc.subjectCollagen-
Palavras-chave: dc.subjectCorticosteroids-
Palavras-chave: dc.subjectGlucocorticoid-
Palavras-chave: dc.subjectHistology-
Palavras-chave: dc.subjectHyaluronic acid-
Palavras-chave: dc.subjectMesenchymal stem cell-
Palavras-chave: dc.subjectOsteoarthritis-
Palavras-chave: dc.subjectTriancinolone acetonide-
Palavras-chave: dc.subjectViscosupplementation-
Título: dc.titlePotential effect of hyaluronic acid and triamcinolone acetate, alone or combined, on chondrogenic differentiation of mesenchymal stem cells-
Título: dc.titleEfecto potencial del ácido hialurónico y del acetato de triamcinolona solos o combinados sobre la diferenciación condrogénica de células-tronco mesenquimales-
Título: dc.titleEfeito potencial do ácido hialurônico e triancinolona acetonida, isolados e combinados, na diferenciação condrogênica de células-tronco mensenquimais-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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