Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorOrtecho-Zuta, Uxua-
Autor(es): dc.creatorde Oliveira Duque, Carla Caroline-
Autor(es): dc.creatorde Oliveira Ribeiro, Rafael Antonio-
Autor(es): dc.creatorLeite, Maria Luísa-
Autor(es): dc.creatorSoares, Diana Gabriela-
Autor(es): dc.creatorHebling, Josimeri-
Autor(es): dc.creatorBriso, André Luiz Fraga-
Autor(es): dc.creatorde Souza Costa, Carlos Alberto-
Data de aceite: dc.date.accessioned2025-08-21T22:23:27Z-
Data de disponibilização: dc.date.available2025-08-21T22:23:27Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jerd.12805-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233243-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233243-
Descrição: dc.descriptionEvaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (ΔE/ΔWI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (ΔE) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for ΔWI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance: Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching.-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials School of Dentistry São Paulo University (USP)-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Esthetic and Restorative Dentistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbleaching-
Palavras-chave: dc.subjectcolor science-
Palavras-chave: dc.subjectdental materials-
Palavras-chave: dc.subjectendo/pulp biology-
Título: dc.titlePolymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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