The Characterisation of the Craniofacial Morphology of Infants Born With Zika Virus; Innovative Approach for Public Health Surveillance and Broad Clinical Applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Glasgow-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Dundee-
Autor(es): dc.contributorUniversity of Baghdad-
Autor(es): dc.contributorRoberto Santos General Hospital-
Autor(es): dc.contributorEdinburgh NHS Lothian-
Autor(es): dc.contributorNHS Greater Glasgow and Clyde Glasgow-
Autor(es): dc.creatorAyoub, Ashraf-
Autor(es): dc.creatorde Freitas Silva, Leonardo-
Autor(es): dc.creatorMossey, Peter-
Autor(es): dc.creatorAl-Rudainy, Dhelal-
Autor(es): dc.creatorde Mattos, Adriana Marques-
Autor(es): dc.creatorGarcia Júnior, Idelmo Rangel-
Autor(es): dc.creatorQuigley, Alan-
Autor(es): dc.creatorJu, Xiangyang-
Data de aceite: dc.date.accessioned2025-08-21T18:58:31Z-
Data de disponibilização: dc.date.available2025-08-21T18:58:31Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-06-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmed.2021.612596-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233240-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233240-
Descrição: dc.descriptionBackground: This study was carried out in response to the Zika virus epidemic, which constituted a public health emergency, and to the 2019 WHO calling for strengthened surveillance for the early detection of related microcephaly. The main aim of the study was to phenotype the craniofacial morphology of microcephaly using a novel approach and new measurements, and relate the characteristics to brain abnormalities in Zika-infected infants in Brazil to improve clinical surveillance. Methods: 3D images of the face and the cranial vault of 44 Zika-infected infants and matched healthy controls were captured using a 3D stereophotogrammetry system. The CT scans of the brain of the infected infants were analysed. Principal component analysis (PCA) was applied to characterise the craniofacial morphology. In addition to the head circumference (HC), a new measurement, head height (HH), was introduced to measure the cranial vault. The level of brain abnormality present in the CT scans was assessed; the severity of parenchymal volume loss and ventriculomegaly was quantified. Student's t-test and Spearman's Rho statistical test have been applied. Findings: The PCA identified a significant difference (p < 0.001) between the cranial vaults and the face of the Zika infants and that of the controls. Spearman's rank-order correlation coefficients show that the head height (HH) has a strong correlation (0.87 in Zika infants; 0.82 in controls) with the morphology of the cranial vaults, which are higher than the correlation with the routinely used head circumference (HC). Also, the head height (HH) has a moderate negative correlation (−0.48) with the brain abnormalities of parenchymal volume loss. Interpretation: It is discovered that the head height (HH) is the most sensitive and discriminatory measure of the severity of cranial deformity, which should be used for clinical surveillance of the Zika syndrome, evaluation of other craniofacial syndromes and assessment of various treatment modalities.-
Descrição: dc.descriptionScottish Craniofacial Research Group Dental School College of MVLS University of Glasgow-
Descrição: dc.descriptionAraçatuba Dental School Univ Estadual Paulista-
Descrição: dc.descriptionScottish Craniofacial Research Group School of Dentistry University of Dundee-
Descrição: dc.descriptionDental School College of MVLS University of Glasgow-
Descrição: dc.descriptionOrthodontic Department College of Dentistry University of Baghdad-
Descrição: dc.descriptionRoberto Santos General Hospital-
Descrição: dc.descriptionUNESP School of Dentistry at Araçatuba São Paulo State University-
Descrição: dc.descriptionDepartment of Paediatric Radiology Royal Hospital for Sick Children Edinburgh NHS Lothian-
Descrição: dc.descriptionScottish Craniofacial Research Group Medical Devices Unit NHS Greater Glasgow and Clyde Glasgow-
Descrição: dc.descriptionAraçatuba Dental School Univ Estadual Paulista-
Descrição: dc.descriptionUNESP School of Dentistry at Araçatuba São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject3D imaging-
Palavras-chave: dc.subjectcraniofacial morphology-
Palavras-chave: dc.subjecthead measurements-
Palavras-chave: dc.subjectprincipal compenent analysis-
Palavras-chave: dc.subjectsurveillance-
Palavras-chave: dc.subjectzika-
Título: dc.titleThe Characterisation of the Craniofacial Morphology of Infants Born With Zika Virus; Innovative Approach for Public Health Surveillance and Broad Clinical Applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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