Adjuvant Therapy with 1% Alendronate Gel for Experimental Periodontitis Treatment in Rats

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Autor(es): dc.contributorThe University of Texas Health Science Center at San Antonio-
Autor(es): dc.contributorNew York University College of Dentistry-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorKajimoto, Natália De Campos-
Autor(es): dc.creatorBuischi, Yvonne De Paiva-
Autor(es): dc.creatorLoomer, Peter Michael-
Autor(es): dc.creatorBromage, Timothy G.-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorFucini, Stephen Enrico-
Autor(es): dc.creatorPola, Natália Marcumini-
Autor(es): dc.creatorPirovani, Beatriz Ommati-
Autor(es): dc.creatorMorábito, Maria Juliana Sismeiro-
Autor(es): dc.creatorde Almeida, Juliano Milanezi-
Autor(es): dc.creatorFurlaneto, Flávia Aparecida Chaves-
Autor(es): dc.creatorNagata, Maria José Hitomi-
Data de aceite: dc.date.accessioned2025-08-21T18:14:08Z-
Data de disponibilização: dc.date.available2025-08-21T18:14:08Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5051/JPIS.2100700035-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233233-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233233-
Descrição: dc.descriptionPurpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.-
Descrição: dc.descriptionDepartment of Periodontics The University of Texas Health Science Center at San Antonio-
Descrição: dc.descriptionDepartment of Periodontology and Implant Dentistry New York University College of Dentistry-
Descrição: dc.descriptionDepartment of Biomaterials & Biomimetics New York University College of Dentistry-
Descrição: dc.descriptionDivision of Histology Department of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDivision of Periodontics Department of Semiology and Clinic Federal University of Pelotas (UFPEL) School of Dentistry-
Descrição: dc.descriptionDivision of Periodontology Department of Surgery and Integrated Clinic São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDivision of Periodontology Departament of Oral Maxillofacial Surgery and Periodontology University of São Paulo (USP) School of Dentistry-
Descrição: dc.descriptionDivision of Histology Department of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDivision of Periodontology Department of Surgery and Integrated Clinic São Paulo State University (UNESP) School of Dentistry-
Formato: dc.format1-12-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontal and Implant Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlendronate-
Palavras-chave: dc.subjectDental scaling-
Palavras-chave: dc.subjectPeriodontal disease-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectRats-
Título: dc.titleAdjuvant Therapy with 1% Alendronate Gel for Experimental Periodontitis Treatment in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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