A new and ecological method to quantify vancomycin in pharmaceutical product by infrared spectrometry

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatordo Nascimento, Patrícia Aleixa-
Autor(es): dc.creatorKogawa, Ana Carolina-
Autor(es): dc.creatorSalgado, Hérida Regina Nunes-
Data de aceite: dc.date.accessioned2025-08-21T21:44:42Z-
Data de disponibilização: dc.date.available2025-08-21T21:44:42Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.17344/acsi.2020.6107-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233170-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233170-
Descrição: dc.descriptionVancomycin, an antimicrobial, does not present quantitative method by infrared spectrometry in the literature for the evaluation of a pharmaceutical product. This technique is considered a clean alternative because in the main, there is no solvent involved and the generation of waste is reduced. So, the aim of this study was to develop and validate a new, ecological, low cost and fast method by infrared spectrometry using KBr and band between 1450-1375 cm-1. It was linear in the range of 1.0-2.0 mg/150 mg, with a correlation coefficient of 0.9994. Selective when the spectra of vancomycin reference and sample were compared. Precise by repeatability (2.29%) and intermediate precision (3.12%). Accurate with average recovery of 99.37% and robust when strength and compression time of the pellets and KBr brand were varied. Considering all the methods found in literature, there is not one using infrared spectrometry for quantitative purpose, so the method developed and validated could be considered an innovation and clean alternative. This is due to the fact that it is fast, easy to handle, low cost, and non-toxic as well as generating minimal waste. The method can be applied in the routine analysis of vancomycin dosage form and is an important option for the current and sustainable pharmaceutical analysis.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionGoverno Brasil-
Descrição: dc.descriptionDepartment of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista - UNESP, São Paulo-
Descrição: dc.descriptionLaboratório de Controle de Qualidade Faculdade de Farmácia Universidade Federal de Goiás - UFG, Goiás-
Descrição: dc.descriptionDepartment of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista - UNESP, São Paulo-
Formato: dc.format313-319-
Idioma: dc.languageen-
Relação: dc.relationActa Chimica Slovenica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGreen analytical chemistry-
Palavras-chave: dc.subjectInfrared spectrometric method-
Palavras-chave: dc.subjectPharmaceutical analysis-
Palavras-chave: dc.subjectSustainable alternative-
Palavras-chave: dc.subjectVancomycin-
Título: dc.titleA new and ecological method to quantify vancomycin in pharmaceutical product by infrared spectrometry-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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