Effects of obesity on the cardiac proteome

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFernandes Vileigas, Danielle-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T21:08:00Z-
Data de disponibilização: dc.date.available2025-08-21T21:08:00Z-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2022-05-01-
Data de envio: dc.date.issued2021-03-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.endmts.2020.100076-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/233113-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/233113-
Descrição: dc.descriptionObesity has reached epidemic proportions in both developed and developing countries. It is currently recognized as a major health concern due to excessive adipose tissue which is associated with a wide range of other medical complications, such as cardiovascular disease. Obesity causes severe changes in the heart and can induce modifications in cardiac structure and function, predisposing the development of heart failure. However, the mechanisms behind functional heart damage when faced with excess adipose tissue are not completely understood. Mass spectrometry-based proteomics is a powerful tool for studying the biology of systems at the protein level. It can provide a systematic, global, unbiased, and quantitative assessment of proteins, clarifying molecular based involvement in disease pathophysiology. Such knowledge is essential for shedding light on diagnosis and the development of therapeutic strategies. Thus, this review summarizes the basis of cardiac remodeling in obesity and current proteomics methods, as well as focusing on the contribution of proteomics in better understanding the molecular mechanisms underlying heart diseases in obesity research.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCAPES: 2014/22152-0-
Descrição: dc.descriptionFAPESP: 2015/16934-8-
Descrição: dc.descriptionFAPESP: 2017/09688-6-
Idioma: dc.languageen-
Relação: dc.relationEndocrine and Metabolic Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiological systems-
Palavras-chave: dc.subjectCardiac remodeling-
Palavras-chave: dc.subjectCardiometabolic disease-
Palavras-chave: dc.subjectCardiovascular diseases-
Palavras-chave: dc.subjectMass spectrometry-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectProteomics-
Título: dc.titleEffects of obesity on the cardiac proteome-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.