A critical review of HPLC-based analytical methods for quantification of Linezolid

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFernandes, Guilherme Felipe dos Santos-
Autor(es): dc.creatorSalgado, Hérida Regina Nunes-
Autor(es): dc.creatorSantos, Jean Leandro dos-
Data de aceite: dc.date.accessioned2025-08-21T22:25:51Z-
Data de disponibilização: dc.date.available2025-08-21T22:25:51Z-
Data de envio: dc.date.issued2022-04-30-
Data de envio: dc.date.issued2022-04-30-
Data de envio: dc.date.issued2020-05-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10408347.2019.1605876-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232878-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232878-
Descrição: dc.descriptionLinezolid is a synthetic antimicrobial agent belonging to the oxazolidinone class. Since its approval in the year 2000 until now, linezolid remains the main representative drug for the oxazolidinone class of drugs, which is used in therapy due to its unique mode of action, which involves inhibition of protein synthesis. As linezolid holds great importance in antimicrobial therapy, it is necessary to compile the various analytical methods that have been reported in the literature for its analysis. Analytical techniques used for pharmaceutical analyses and therapeutic drug monitoring play an important role in comprehending the aspects regarding bioavailability, bioequivalence, and therapeutic monitoring during patient follow-ups. Even though linezolid has had the approval for clinical use for more than 18 years now, most of the analytical methods for its determination reported in the scientific literature are the ones which utilize HPLC. Therefore, the present review provides a summary of the HPLC-based methods used in the determination and quantification of linezolid in different matrices since the time of its discovery.-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University-
Formato: dc.format196-211-
Idioma: dc.languageen-
Relação: dc.relationCritical Reviews in Analytical Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnalytical methods-
Palavras-chave: dc.subjectHPLC-
Palavras-chave: dc.subjectLinezolid-
Palavras-chave: dc.subjectmass spectroscopy-
Palavras-chave: dc.subjectquality control-
Palavras-chave: dc.subjectultraviolet-
Título: dc.titleA critical review of HPLC-based analytical methods for quantification of Linezolid-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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