Oxidative stress and sickle cell disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDa Silva, Danilo Grünig Humberto-
Autor(es): dc.creatorJunior, Edis Belini-
Autor(es): dc.creatorBonini-Domingos, Claudia Regina-
Autor(es): dc.creatorDe Almeida, Eduardo Alves-
Data de aceite: dc.date.accessioned2025-08-21T20:05:31Z-
Data de disponibilização: dc.date.available2025-08-21T20:05:31Z-
Data de envio: dc.date.issued2022-04-30-
Data de envio: dc.date.issued2022-04-30-
Data de envio: dc.date.issued2017-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1201/b20228-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232785-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232785-
Descrição: dc.descriptionSickle cell disease (SCD) embraces a group of genetic hemolytic disorders associated with high morbidity and mortality. SCD is characterized by a complex pathophysiology initiated by hemoglobin S (HbS) polymerization that triggers a cascade of pathological events, including vaso-occlusion episodes, hemolysis, endothelial dysfunction, inflammation, hypercoagulability, reperfusion injury, and hypoxemia, leading to devastating clinical manifestations. Although SCD is one of the first disorders to be clearly defined at the molecular level, the genetic understanding of the basis for the disease expression variability is still not fully explained. In this intriguing scenario, oxidative stress plays a major role because it acts as both causing and being caused by SCD complications.-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Biology Sao Paulo State University-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Sao Paulo State University-
Descrição: dc.descriptionDepartment of Biology Sao Paulo State University-
Formato: dc.format335-347-
Idioma: dc.languageen-
Relação: dc.relationReactive Oxygen Species in Biology and Human Health-
???dc.source???: dc.sourceScopus-
Título: dc.titleOxidative stress and sickle cell disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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