Effect of Qualea multiflora on macrophages and tumour cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCarli, Camila B. de A.-
Autor(es): dc.creatorQuilles, Marcela B.-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorCarlos, Iracilda Z.-
Data de aceite: dc.date.accessioned2025-08-21T19:54:36Z-
Data de disponibilização: dc.date.available2025-08-21T19:54:36Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2013-12-23-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232188-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232188-
Descrição: dc.descriptionSpecies of the genus Qualea are used by the Brazilian people as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions βF and TF (rich in β-sitosterol and terpenoids, respectively) obtained from Qualea multiflora on nitric oxide production, cytokines (IL-1, IL- 10, IL-12, and TNF-α) and the transcription factor NF-κB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary and pulmonary tumoural cell lineages, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-α; about 32% of NF-κB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.-
Descrição: dc.descriptionUNESP São Paulo State University, C. Postal 502, 14801-902, Araraquara, SP-
Descrição: dc.descriptionUNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP-
Descrição: dc.descriptionUNESP São Paulo State University, C. Postal 502, 14801-902, Araraquara, SP-
Descrição: dc.descriptionUNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP-
Formato: dc.format1516-1521-
Idioma: dc.languageen-
Relação: dc.relationLatin American Journal of Pharmacy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectMacrophages-
Palavras-chave: dc.subjectQualea multiflora-
Título: dc.titleEffect of Qualea multiflora on macrophages and tumour cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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