Increment of antimycobaterial activity on lichexanthone derivatives

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Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMicheletti, Ana Camila-
Autor(es): dc.creatorHonda, Neli Kika-
Autor(es): dc.creatorPavan, Fernando R.-
Autor(es): dc.creatorLeite, Clarice Q.F.-
Autor(es): dc.creatorDe Fatima Cepa Matos, Maria-
Autor(es): dc.creatorPerdomo, Renata Trentin-
Autor(es): dc.creatorBogo, Danielle-
Autor(es): dc.creatorAlcantara, Glaucia Braz-
Autor(es): dc.creatorBeatriz, Adilson-
Data de aceite: dc.date.accessioned2025-08-21T21:33:20Z-
Data de disponibilização: dc.date.available2025-08-21T21:33:20Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2013-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1573406411309070003-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232181-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232181-
Descrição: dc.descriptionA new dihydropyranexanthone derived from the natural xanthone lichexanthone (1) was synthesised and, together with other 18 derivatives including ω-bromo and ω-aminoalkoxylxanthones (containing methyl, ethyl, propyl, tertbutylamino and piperidinyl moieties), were tested against Mycobacterium tuberculosis. Nine ω-aminoalkoxylxanthones showed good antimycobacterial activity, and their in vitro cytotoxicity was determined using VERO cells in order to calculate the selectivity index (SI). One of these nitrogenated xanthone derivatives showed very promising results, with MIC of 2.6 μM and SI of 48. This MIC is comparable to values found in first and second line drugs commonly used to treat TB. In order to understand better about this compound, it was evaluated together with two other ones that showed good SI, against resistant clinical strains of M. tuberculosis to verify the existence of cross-resistance. A chemometrical approach was useful to establish a pattern of antitubercular activity among the group of ω- aminoalkoxylxanthones, according to some structural and chemical features. © 2013 Bentham Science Publishers.-
Descrição: dc.descriptionCentro de Ciências Exatas e Tecnologia Universidade Federal de Mato Grosso Do sul, P. O. Box 549, Campo Grande, MS-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista, 14801-902 Araraquara, SP-
Descrição: dc.descriptionCentro de Ciências Biológica e da Saúde Universidade Federal de Mato Grosso Do sul, P. O. Box 549, Campo Grande, MS-
Descrição: dc.descriptionFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista, 14801-902 Araraquara, SP-
Formato: dc.format904-910-
Idioma: dc.languageen-
Relação: dc.relationMedicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChemometrics-
Palavras-chave: dc.subjectLichen-
Palavras-chave: dc.subjectStructural modifications-
Palavras-chave: dc.subjectTuberculosis-
Palavras-chave: dc.subjectXanthone-
Título: dc.titleIncrement of antimycobaterial activity on lichexanthone derivatives-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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