Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSaúde e Tecnologia-UFMA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRibeiro, Paulo R.S.-
Autor(es): dc.creatorPezza, Leonardo-
Autor(es): dc.creatorPezza, Helena R.-
Autor(es): dc.creatorTognolli, João O.-
Data de aceite: dc.date.accessioned2025-08-21T21:12:14Z-
Data de disponibilização: dc.date.available2025-08-21T21:12:14Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-08-24-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232070-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232070-
Descrição: dc.descriptionA new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized using chemometric methods of fractional factorial and central composite design. At the optimum reaction conditions, the rectilinear calibration graphs were obtained in the concentration range 1.86 x 10-4 to 7.38 x 10-4 mol/L captopril with an excellent correlation coefficient (r = 0.9996). The proposed procedure could be applied successfully for the determination of the investigated drug in their pharmaceutical dosage forms with a good precision and accuracy compared to official and reported method as revealed by F- and t-tests at 95% confidence level. No interference was observed from common excipients in formulations.-
Descrição: dc.descriptionCentro de Ciências Sociais Saúde e Tecnologia-UFMA, CEP 65900-000, Imperatriz, MA-
Descrição: dc.descriptionInstituto de Química-UNESP, P.O. Box 355, CEP 14801-970, Araraquara, SP-
Descrição: dc.descriptionInstituto de Química-UNESP, P.O. Box 355, CEP 14801-970, Araraquara, SP-
Formato: dc.format1158-1166-
Idioma: dc.languageen-
Relação: dc.relationLatin American Journal of Pharmacy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaptopril-
Palavras-chave: dc.subjectCharge transfer complex-
Palavras-chave: dc.subjectChemometric methods-
Palavras-chave: dc.subjectPharmaceuticals formulations-
Título: dc.titleSpectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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