Effect of Byrsonima crassa and phenolic constituents on Helicobacter pylori-induced neutrophils oxidative burst

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBonacorsi, Cibele-
Autor(es): dc.creatorRaddi, Maria Stella G.-
Autor(es): dc.creatorda Fonseca, Luiz Marcos-
Autor(es): dc.creatorSannomiya, Miriam-
Autor(es): dc.creatorVilegas, Wagner-
Data de aceite: dc.date.accessioned2025-08-21T23:34:03Z-
Data de disponibilização: dc.date.available2025-08-21T23:34:03Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2012-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms13010133-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232052-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232052-
Descrição: dc.descriptionByrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-α-Larabinopyranoside > quercetin 3-O-β-D-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 μg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms. © 2012 by the authors; licensee MDPI, Basel, Switzerland.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, 14801-902-
Descrição: dc.descriptionSchool of Arts, Sciences and Humanities, University of São Paulo (USP), São Paulo, SP, 03828-000-
Descrição: dc.descriptionInstitute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-900-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, 14801-902-
Descrição: dc.descriptionInstitute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-900-
Formato: dc.format133-141-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant activity-
Palavras-chave: dc.subjectByrsonima crassa-
Palavras-chave: dc.subjectChemiluminescence-
Palavras-chave: dc.subjectGastric ulcers-
Palavras-chave: dc.subjectHelicobacter pylori-
Palavras-chave: dc.subjectPhenolic compounds-
Título: dc.titleEffect of Byrsonima crassa and phenolic constituents on Helicobacter pylori-induced neutrophils oxidative burst-
Tipo de arquivo: dc.typelivro digital-
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