Spectrophotometric determination of paracetamol in pharmaceuticals using microwave-assisted hydrolysis and a micellar medium

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSequinel, Rodrigo-
Autor(es): dc.creatorRufino, José L.-
Autor(es): dc.creatorPezza, Helena R.-
Autor(es): dc.creatorPezza, Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T21:38:16Z-
Data de disponibilização: dc.date.available2025-08-21T21:38:16Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-12-02-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232040-
Descrição: dc.descriptionA new spectrophotometric method employing a micellar medium is proposed for the determination of paracetamol in pharmaceuticals. The method is based on the acid hydrolysis of paracetamol to p-aminophenol (PAP), which under acidic conditions reacts with p-dimethylaminocinnamaldehyde (p-DAC), producing a red compound (λmax = 530 nm). This reaction can be enhanced five-fold in the presence of sodium dodecyl sulfate (SDS). The effects of all the parameters involved in both the hydrolysis step and the derivatization reaction were investigated using experimental design methodologies. The method presented a linear range of 0.2 to 3.9 μg mL-1 and an excellent correlation coefficient (r = 0.9996). The limit of detection was estimated to be 30.0 μg/L. The technique was successfully applied for the determination of paracetamol in commercial brands of pharmaceuticals. No interferences from the excipients commonly used in commercial formulations were observed, and the results obtained compared favorably with measurements made using the United States Pharmacopeia procedure, at a 95% confidence level.-
Descrição: dc.descriptionInstituto de Química de Araraquara UNESP Univ. Estadual Paulista, PO Box 355, CEP 14801-970, Araraquara,SP-
Descrição: dc.descriptionInstituto de Química de Araraquara UNESP Univ. Estadual Paulista, PO Box 355, CEP 14801-970, Araraquara,SP-
Formato: dc.format1330-1335-
Idioma: dc.languageen-
Relação: dc.relationLatin American Journal of Pharmacy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMicrowave-
Palavras-chave: dc.subjectp-dimethylaminocinnamaldehyde-
Palavras-chave: dc.subjectParacetamol-
Palavras-chave: dc.subjectSpectrophotometry-
Palavras-chave: dc.subjectSurfactant-
Título: dc.titleSpectrophotometric determination of paracetamol in pharmaceuticals using microwave-assisted hydrolysis and a micellar medium-
Tipo de arquivo: dc.typelivro digital-
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