Upregulation of mRNA myocardium calcium handling in rats submitted to exercise and food restriction

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto de Ciências da Saúde - Universidade Federal de Mato Grosso - UFMT-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSugizaki, Mário Mateus-
Autor(es): dc.creatorLeopoldo, Ana Paula Lima-
Autor(es): dc.creatorConde, Sandro José-
Autor(es): dc.creatorCampos, Dijon Salome-
Autor(es): dc.creatorDamato, Ricardo-
Autor(es): dc.creatorLeopoldo, André Soares-
Autor(es): dc.creatordo Nascimento, André Ferreira-
Autor(es): dc.creatorJúnior, Silvio de Assis Oliveira-
Autor(es): dc.creatorCicogna, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T16:59:56Z-
Data de disponibilização: dc.date.available2025-08-21T16:59:56Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2011-07-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/232028-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/232028-
Descrição: dc.descriptionBackground: Chronic exercise and food restriction (FR) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (TH) status. Objective: Evaluate the association of chronic exercise and FR on serum thyroid hormones and gene transcription of molecular structures of intracellular calcium transients and thyroid receptors in myocardium of rats. Methods: Male Wistar Kyoto rats, divided into two groups: control (C, n = 7), FR (R50', n = 7), chronic exercise (EX, n = 7) and chronic exercise + FR (EX50', n = 7). FR was of 50% and exercise was swimming (1 hour/day, 5 days/ week, during 12 weeks). Serum concentrations of T3', T4 and TSH were determined. The mRNA gene expression of the sarcoplasmatic reticulum calcium pump (SERCA2a), phospholamban (PLB), Na+/Ca+2 exchanger (NCX), calcium channel L-type (L-channel), ryanodine (RYR), calsequestrin (CQS) and HT receptor (TRα1 and TRβ1) of the myocardium was performed by PCR real-time. Results: FR reduced serum levels of T4 and TSH and TRα1 mRNA and increased the expression of PLB, NCX and L-channel. Exercise increased the TRβ1 receptor, L-channel and NCX. The association of exercise and FR reduced plasma T4 and TSH, TRβ1 mRNA increase, SERCA2a, NCX and PLB, and there was a significant correlation of TRβ1 with CQS and NXC. Conclusion: Chronic exercise and food restriction increased the mRNA of transient Ca2+ proteins; however, TH - receptor axis cannot participate in the transcription of mRNA of myocardial calcium transient proteins.-
Descrição: dc.descriptionInstituto de Ciências da Saúde - Universidade Federal de Mato Grosso - UFMT Campus de Sinop, Botucatu-
Descrição: dc.descriptionCuiabá, MT Faculdade de Medicina - Universidade Estadual Paulista - UNESP Campus de Botucatu, Botucatu-
Descrição: dc.descriptionCuiabá, MT Faculdade de Medicina - Universidade Estadual Paulista - UNESP Campus de Botucatu, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationArquivos Brasileiros de Cardiologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium-
Palavras-chave: dc.subjectCaloric restriction-
Palavras-chave: dc.subjectCarrier proteins-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectMyocardium-
Palavras-chave: dc.subjectThyroid hormones-
Título: dc.titleUpregulation of mRNA myocardium calcium handling in rats submitted to exercise and food restriction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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