Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Barros, Reginaldo-
Autor(es): dc.creatorZornoff, Leonardo A. M.-
Autor(es): dc.creatorRibeiro, Henrique B.-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorPadovani, Carlos R.-
Autor(es): dc.creatorAragon, Flávio F.-
Autor(es): dc.creatorCicogna, Antonio C.-
Data de aceite: dc.date.accessioned2025-08-21T20:26:35Z-
Data de disponibilização: dc.date.available2025-08-21T20:26:35Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2010-08-13-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231941-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231941-
Descrição: dc.descriptionBackground: The aim of this study was to analyze stable hypertrophied myocardial function and its response to inotropic maneuvers in rats submitted to renovascular hypertension for a 10-week period (RHT group, n=10). Material/Methods: Myocardial performance was studied in isolated left ventricle papillary muscles in isometric contraction under the following conditions: at postrest contraction of 30 seconds (PRC), at extracellular calcium (ECa2+) chloride concentration of 1.25 and 5.20 mM, and after beta-adrenergic stimulation with 10-6 M isoproterenol (ISOP). Results: The results were compared with normotensive Wistar controls rats (C group, n=10). In basal condition, resting tension, and contraction time (TPT) were greater, while relaxation time (RT50) tended to be longer in RHT than C group. PRC and ISOP promoted a similar change in muscle function response intensity (Δ) in both groups. ECa2+ shift did not change TPT in the C group and decreased TPT in the RHT animals; Δ was different between these groups. RT50 increased in C and decreased in RHT, both without statistical significance; however, Δ was different. Conclusions: These results suggest that hypertrophied myocardial dysfunction may be attibuted to changes in intracellular calcium cycling. © Med Sci Monit, 2010.-
Descrição: dc.descriptionBotucatu Medical School UNESP - São Paulo State University, Botucatu-
Descrição: dc.descriptionBotucatu Medical School UNESP - São Paulo State University, Botucatu-
Idioma: dc.languageen-
Relação: dc.relationCase Reports and Clinical Practice Review-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium isoproterenol-
Palavras-chave: dc.subjectMyocardium function-
Palavras-chave: dc.subjectPapillary muscle-
Palavras-chave: dc.subjectRenovascular hypertension-
Título: dc.titleHypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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