Efectos de la asociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio Morfométrico

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of São José do Rio Preto-
Autor(es): dc.creatorPadulla, Susimary Aparecida Trevizan-
Autor(es): dc.creatorAzoubel, Reinaldo-
Autor(es): dc.creatorBonfim, Mariana Rotta-
Autor(es): dc.creatorAccioly, Marilita Falângola-
Autor(es): dc.creatorCamargo Filho, José Carlos Silva-
Autor(es): dc.creatorPadovani, João Armando-
Autor(es): dc.creatorBrandão, Antônio Carlos-
Autor(es): dc.creatorSouza, Dorotéia Rossi Silva-
Data de aceite: dc.date.accessioned2025-08-21T15:23:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:23:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0717-95022009000100015-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231880-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231880-
Descrição: dc.descriptionPhysical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestion, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180°C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p<0.05. It was verified that the group receiving statin presented values statistically significant in comparison to the other groups, in the tridimensional and linear variables. The exercised and statin group, the values obtained in the morphometric analyses were similar to the control group. It is suggested that statins alone can cause alterations in the nucleus of cardiac cells that can be related to apoptosis occurrence and, when exercise is practiced associated to statin administration, the effects of statin can be reduced, what can be related to beneficial adaptations of cardiac mitochondrial in response to physical exercise, turning them more resistant to apoptotic stimuli.-
Descrição: dc.descriptionPhysiotherapy Department São Paulo State University-
Descrição: dc.descriptionUniversity of São José do Rio Preto-
Descrição: dc.descriptionSão Paulo State University-
Descrição: dc.descriptionPhysiotherapy Department São Paulo State University-
Descrição: dc.descriptionSão Paulo State University-
Formato: dc.format83-88-
Idioma: dc.languagees-
Relação: dc.relationInternational Journal of Morphology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiomyocite nuclei-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors-
Título: dc.titleEfectos de la asociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio Morfométrico-
Título: dc.titleEffects of statin and aerobic physical exercise association in the cardiomyocytes of the rat. morphometric study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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