The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorKatayama, Pedro L.-
Autor(es): dc.creatorLeirão, Isabela P.-
Autor(es): dc.creatorKanashiro, Alexandre-
Autor(es): dc.creatorLuiz, João P.M.-
Autor(es): dc.creatorCunha, Fernando Q.-
Autor(es): dc.creatorNavegantes, Luiz C.C.-
Autor(es): dc.creatorMenani, Jose V.-
Autor(es): dc.creatorZoccal, Daniel B.-
Autor(es): dc.creatorColombari, Débora S.A.-
Autor(es): dc.creatorColombari, Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T19:28:13Z-
Data de disponibilização: dc.date.available2025-08-21T19:28:13Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbi.2022.03.014-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231640-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231640-
Descrição: dc.descriptionRecent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-α increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-α-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-α administration were higher in rats subjected to either carotid body ablation or splanchnic sympathetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-α to activate a counteracting sympathetic anti-inflammatory mechanism.-
Descrição: dc.descriptionBooz Allen Foundation-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Neurosciences and Behavior Ribeirão Preto Medical School University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirão Preto Medical School University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Physiology Ribeirão Preto Medical School University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo-
Descrição: dc.descriptionBooz Allen Foundation: 2015/23467-7-
Descrição: dc.descriptionBooz Allen Foundation: 2019/11196-0-
Descrição: dc.descriptionBooz Allen Foundation: PROPE-UNESP-
Formato: dc.format370-386-
Idioma: dc.languageen-
Relação: dc.relationBrain, Behavior, and Immunity-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarotid body-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNeural circuits-
Palavras-chave: dc.subjectNeuroimmune interactions-
Palavras-chave: dc.subjectNeuroimmunomodulation-
Palavras-chave: dc.subjectSympathetic nervous system-
Título: dc.titleThe carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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