Toxicological impact of SARS-CoV-2 on the health of the neotropical fish, Poecilia reticulata

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Autor(es): dc.contributorGoiano Federal Institute-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorAssiut University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMalafaia, Guilherme-
Autor(es): dc.creatorAhmed, Mohamed Ahmed Ibrahim-
Autor(es): dc.creatorSouza, Sindoval Silva de-
Autor(es): dc.creatorRezende, Fernanda Neves Estrela-
Autor(es): dc.creatorFreitas, Ítalo Nascimento-
Autor(es): dc.creatorda Luz, Thiarlen Marinho-
Autor(es): dc.creatorda Silva, Abner Marcelino-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorBraz, Helyson Lucas Bezerra-
Autor(es): dc.creatorJorge, Roberta Jeane Bezerra-
Autor(es): dc.creatorSanches, Paulo R.S.-
Autor(es): dc.creatorMendonça-Gomes, Juliana Moreira-
Autor(es): dc.creatorCilli, Eduardo M.-
Autor(es): dc.creatorAraújo, Amanda Pereira da Costa-
Data de aceite: dc.date.accessioned2025-08-21T17:35:26Z-
Data de disponibilização: dc.date.available2025-08-21T17:35:26Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.aquatox.2022.106104-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/231616-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/231616-
Descrição: dc.descriptionThere have been significant impacts of the current COVID-19 pandemic on society including high health and economic costs. However, little is known about the potential ecological risks of this virus despite its presence in freshwater systems. In this study, we aimed to evaluate the exposure of Poecilia reticulata juveniles to two peptides derived from Spike protein of SARS-CoV-2, which was synthesized in the laboratory (named PSPD-2002 and PSPD-2003). For this, the animals were exposed for 35 days to the peptides at a concentration of 40 µg/L and different toxicity biomarkers were assessed. Our data indicated that the peptides were able to induce anxiety-like behavior in the open field test and increased acetylcholinesterase (AChE) activity. The biometric evaluation also revealed that the animals exposed to the peptides displayed alterations in the pattern of growth/development. Furthermore, the increased activity of superoxide dismutase (SOD) and catalase (CAT) enzymes were accompanied by increased levels of malondialdehyde (MDA), reactive oxygen species (ROS) and hydrogen peroxide (H2O2), which suggests a redox imbalance induced by SARS-CoV-2 spike protein peptides. Moreover, molecular docking analysis suggested a strong interaction of the peptides with the enzymes AChE, SOD and CAT, allowing us to infer that the observed effects are related to the direct action of the peptides on the functionality of these enzymes. Consequently, our study provided evidence that the presence of SARS-CoV-2 viral particles in the freshwater ecosystems offer a health risk to fish and other aquatic organisms.-
Descrição: dc.descriptionBiological Research Laboratory Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute, Urutaí Campus, Rodovia Geraldo Silva Nascimento, 2,5km, Zona Rural CEP, GO-
Descrição: dc.descriptionPost-Graduation Program in Biotechnology and Biodiversity Goiano Federal Institution and Federal University of Goiás, GO-
Descrição: dc.descriptionPost-Graduation Program in Ecology and Conservation of Natural Resources Federal University of Uberlândia, MG-
Descrição: dc.descriptionPlant Protection Department Faculty of Agriculture Assiut University-
Descrição: dc.descriptionPost-Graduation Programa in Environmental Sciences Federal University of Goiás, GO-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Sciences University of Sao Paulo, SP-
Descrição: dc.descriptionDrug Research and Development Center Federal University of Ceará, CE-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceará, CE-
Descrição: dc.descriptionInstituto de Química Universidade Estadual Paulista, SP-
Descrição: dc.descriptionDepartamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo, SP-
Descrição: dc.descriptionInstituto de Química Universidade Estadual Paulista, SP-
Idioma: dc.languageen-
Relação: dc.relationAquatic Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBehavior-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectFish-
Palavras-chave: dc.subjectREDOX unbalance-
Palavras-chave: dc.subjectViral particles-
Palavras-chave: dc.subjectWater pollution-
Título: dc.titleToxicological impact of SARS-CoV-2 on the health of the neotropical fish, Poecilia reticulata-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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